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EC number: 620-216-4 | CAS number: 298692-41-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-02-06 - 2001-03-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- isopropyl (diaminophosphoryl) carbamate
- Cas Number:
- 298692-41-8
- Molecular formula:
- C4H12N3O3P
- IUPAC Name:
- isopropyl (diaminophosphoryl) carbamate
- Details on test material:
- - Analytical purity: > 95%
- Lot/batch No.: S-2
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 6 weeks old, nulliparous, non-pregnant,
mean body weight: males: 240g (n=3)
females: 204 g (n=6)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: suspension in 0.5 % solution of Tylose MH 1000 in deionised water
- Doses:
- 200 mg/kg, 2000 mg/kg
- No. of animals per sex per dose:
- 200 mg/kg: 3 female animals
2000 mg/kg: 3 female and 3 male animals - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs: once daily, body weight: day 0, 7, 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology, - Statistics:
- Body weights and body weight gain
Calculation of group mean values and standard deviations
Comparism with historical control data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- Animals were observed for mortality and morbidity continuously on the day of administration and once daily thereafter (in the morning).
Number of dead animals (200 mg/kg b.w.): 0
Number of deaad animals (2000 mg/kg b.w.): 2 females (67 %) - Clinical signs:
- other: The animals were monitored for general clinical condition continuously on the day of the administration and once daily thereafter (in the morning). The following signs were given predominant consideration: changes in skin, fur, eyes and mucous membranes,
- Gross pathology:
- At the end of the observation period all surviving animals were killed by CO2 inhalation. All animals were examined externally. The cranial, thoracic and abdominal cavities were then opened and examined macroscopically. Punctae haemorrhages in the glandular stomach membrane, a reddish brown discoloured intestine content and many atelectatic areas in the lung were observed in one died female animal. The remaining animals showed only atelectatic areas in the lung.
Macroscopic pathological findings were not observed in the surviving animals. - Other findings:
- non
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information symbol of danger: Xn Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity of N-(Isopropoxycarbonyl) phosphoric acid triamide was tested in Charles River Wistar rats. The test item was administred at the single dose of 2000 mg/kg body weight (b.w.) to 3 male and 3 female animals each and at the single dose of 200 mg/kg b.w. to 3 female animals by gavage.The mortality at 2000 mg/kg was 67% (females). At 200 mg/kg non of the animals died.
- Executive summary:
The acute oral toxicity of N-(Isopropoxycarbonyl) phosphoric acid triamide was tested in Charles River Wistar rats. The test item was administered at a dose of 2000 mg/kg body weight (b.w.) to 3 male and 3 female animals each and at a dose of 200 mg/kg b.w. to 3 female animals by gavage.The mortality at 2000 mg/kg was 67% (females). At 200 mg/kg non of the animals died.
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