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EC number: 418-370-0 | CAS number: 143925-92-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-06-18 to 1999-09-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study. No depuration phase.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Deviations:
- yes
- Remarks:
- no depuration phase
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
48hr-LC50 to Orange killifish : > 10 mg/L - Radiolabelling:
- yes
- Details on sampling:
- - Sampling intervals/frequency for test organisms:
After the start of the exposure test, 3 fish each were sampled from Concentration Level 1 and 2 in Weeks 2, 4, 6 and 8 and the concentration of the test substance in a fish body was measured using 2 fish of them. In Week 8, the measurement of Concentration Level 2 was also performed in the third fish because the preliminary measurement result to decide continuation of the test varied between 2 fish.
- Sampling intervals/frequency for test medium samples:
Concentrations of the test substance in water were measured periodically twice weekly. - Vehicle:
- yes
- Remarks:
- HCO-20 and tetrahydrofuran
- Details on preparation of test solutions, spiked fish food or sediment:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 14C-radiolabeled compound was synthesized and used as tracer for the test, because it was difficult to analyze the test substance in water and fish by ordinary method.
The stock feed solution supplied to the dilution tank using a metering pump, mixed with the dilution water [dechlorinated water: dechlorinated water of Yokohama municipal tap water with activated charcoal (conformed to the water standard for fisheries)] supplied from the metering pump for the supply of the dilution water to adjust to the designated concentration of the test solution, and supplied to the breeding water tank. - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Carp
- Fat content measured : 4.1 % (n=4, 3.5-4.6 %)
Test fish: Carp (Cyprinus carpio)
Source of supply: Sankyo Suisan Co., Ltd. (1-1 Ichigaya-tamachi, Shinjuku-ku, Tokyo)
Supply date: December 8, 1998
Lot: 98-K-1208
Body length: 9.4 – 12.2 cm
Body weight: 23.09 – 40.00 g
Water temperature: 25 ± 2 ºC (measured value for 1 week prior to the test)
Period: For at least 1 week
Food: Minipet, Kyorin Co., Ltd.
Feeding: 2% of fish body weight (every day except for holidays)
Ratio of dead fish in the week before the test: 0% - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
- Hardness:
- not indicated
- Test temperature:
- not indicated
- pH:
- not indicated
- Dissolved oxygen:
- at least 4 mg/L
- TOC:
- not indicated
- Salinity:
- n/a
- Details on test conditions:
- TEST SYSTEM
Type of flow-through: Continuous flow-through diluter system
Volume of dilution water supplied: 300 L/day (about 7 exchanges/day; 45 L aquarium)
Volume of the stock feed solution supplied: Level 1: 12 mL/day, Level 2: 12 mL/day
Designated temperature: 25 ± 2 ºC
Dissolved oxygen concentration: At least 4 mg/L
Aeration: Aerated all the time.
Food type: Minipet, Kyorin Co., Ltd.
Feeding: 2% of fish body weight (every day except for holidays)
Breeding density (at the start of test):
Level 1: 22 fish/45 L breeding water
Level 2: 22 fish/45 L breeding water
Control level: 12 fish/45 L breeding water
Breeding period: 8 weeks (exposure) - Nominal and measured concentrations:
- Nominal:
High exposure level: 0.01 mg/L
Low exposure level: 0.001 mg/L
Control: 0 µg/mL
Measured:
High exposure level: 0.0099 to 0.0101 µg/mL
Low exposure level: 0.00103 to 0.00109 µg/mL - Reference substance (positive control):
- no
- Details on estimation of bioconcentration:
- No depuration phase.
- Conc. / dose:
- 0.01 mg/L
- Type:
- BCF
- Value:
- >= 27 - <= 153 dimensionless
- Basis:
- not specified
- Calculation basis:
- steady state
- Remarks on result:
- other:
- Conc. / dose:
- 0.001 mg/L
- Type:
- BCF
- Value:
- >= 27 - <= 87 dimensionless
- Basis:
- not specified
- Calculation basis:
- steady state
- Remarks on result:
- other:
- Results with reference substance (positive control):
- no reference substance
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OASIS Catalogic v5.12.1
2. MODEL (incl. version number)
BCF base-line model v02.09 - July 2017
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See section 'Test Material'.
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached QMRF.
5. APPLICABILITY DOMAIN
See attached QPRF.
6. ADEQUACY OF THE RESULT
- The model is scientifically valid (see attached QMRF).
- The model estimates the Bioconcentration factor (BCF) as required information point according to Regulation (EC) No 1907/2006 [REACH], Annex IX, 9.3.2 Bioaccumulation in aquatic species (preferably fish);
further related predictions: Apparent effect of mitigating factors / Maximum bioconcentration factor (BCFmax) / Maximum diameter of energetically stable conformers / Whole body primary biotransformation half-life / Metabolic biotransformation rate constant Km / Metabolites and their quantitative distribution
- See attached QPRF for reliability assessment. - Principles of method if other than guideline:
- Calculation using Catalogic v.5.12.1, BCF base-line model v.02.09
- GLP compliance:
- no
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: OASIS Catalogic v5.12.1 [BCF base line model - v.02.09] - Key result
- Type:
- BCF
- Value:
- 7.4 L/kg
- Remarks on result:
- other: considering all mitigating factors; the substance is not completely within the applicability domain of the model.
- Type:
- BCF
- Value:
- 9.4 L/kg
- Remarks on result:
- other: BCF max: without considering any mitigating factors; the substance is not completely within the applicability domain of the model.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OASIS Catalogic v5.12.1
2. MODEL (incl. version number)
BCF base-line model v02.09 - July 2017
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See section 'Test Material'.
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached QMRF.
5. APPLICABILITY DOMAIN
See attached QPRF.
6. ADEQUACY OF THE RESULT
- The model is scientifically valid (see attached QMRF).
- The model estimates the Bioconcentration factor (BCF) as required information point according to Regulation (EC) No 1907/2006 [REACH], Annex IX, 9.3.2 Bioaccumulation in aquatic species (preferably fish);
further related predictions: Apparent effect of mitigating factors / Maximum bioconcentration factor (BCFmax) / Maximum diameter of energetically stable conformers / Whole body primary biotransformation half-life / Metabolic biotransformation rate constant Km / Metabolites and their quantitative distribution
- See attached QPRF for reliability assessment. - Principles of method if other than guideline:
- Calculation using Catalogic v.5.12.1, BCF base-line model v.02.09
- GLP compliance:
- no
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: OASIS Catalogic v5.12.1 [BCF base line model - v.02.09] - Key result
- Type:
- BCF
- Value:
- 7.4 L/kg
- Remarks on result:
- other: considering all mitigating factors; the substance is within the applicability domain of the model.
- Type:
- BCF
- Value:
- 9.3 L/kg
- Remarks on result:
- other: BCF max: without considering any mitigating factors; the substance is within the applicability domain of the model.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OASIS Catalogic v5.12.1
2. MODEL (incl. version number)
BCF base-line model v02.09 - July 2017
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See section 'Test Material'.
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached QMRF.
5. APPLICABILITY DOMAIN
See attached QPRF.
6. ADEQUACY OF THE RESULT
- The model is scientifically valid (see attached QMRF).
- The model estimates the Bioconcentration factor (BCF) as required information point according to Regulation (EC) No 1907/2006 [REACH], Annex IX, 9.3.2 Bioaccumulation in aquatic species (preferably fish);
further related predictions: Apparent effect of mitigating factors / Maximum bioconcentration factor (BCFmax) / Maximum diameter of energetically stable conformers / Whole body primary biotransformation half-life / Metabolic biotransformation rate constant Km / Metabolites and their quantitative distribution
- See attached QPRF for reliability assessment. - Principles of method if other than guideline:
- Calculation using Catalogic v.5.12.1, BCF base-line model v.02.09
- GLP compliance:
- no
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: OASIS Catalogic v5.12.1 [BCF base line model - v.02.09] - Key result
- Type:
- BCF
- Value:
- 7.4 L/kg
- Remarks on result:
- other: considering all mitigating factors; the substance is not completely within the applicability domain of the model.
- Type:
- BCF
- Value:
- 12.2 L/kg
- Remarks on result:
- other: BCF max: without considering any mitigating factors; the substance is not completely within the applicability domain of the model.
Referenceopen allclose all
Description of key information
Does not accumulate in organisms.
Key value for chemical safety assessment
Additional information
To assess the bioaccumulation potential of the test substance, a GLP study following the procedures of the OECD guideline 305 C is available. In this flow-through test using Cyprinus carpio as test species a BCF < 153 for the whole test material was determined (Mitsubishi Chemical Safety Institute LTD 8B772G, 1999).
Additionally, QSAR calculations with the main component and two relevant by-products have been conducted with Catalogic v5.12.1, BCF base-line model v.02.09. Taking all mitigating factors into account, the BCF was < 10 for all three compounds. Even the BCF max. was well below 20. The average maximum diameter was >> 1.7 nm which is further proof that uptake through biological membranes is negligible (ECHA Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT/vPvB assessment).
Therefore, none of the components of the substance is expected to be bioaccumulative. The BCF is << 500.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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