Registration Dossier
Registration Dossier
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EC number: 443-510-2 | CAS number: 738587-10-5
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.64 mg/m³
DNEL related information
- Overall assessment factor (AF):
- 300
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
DNEL related information
- Overall assessment factor (AF):
- 300
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Workers - Hazard for the eyes
Additional information - workers
Local
No acute effects have been observed following exposure to S190700 and therefore no acute DNELs are required.
Systemic
The only long-term test conducted on S190700 is a 28-day repeated dose oral toxicity study. The only toxicologically significant findings observed in this study were in the 1000 mg/kg/day group and were restricted to agglomeration of secretion and mucous cell hyperplasia in the gastric mucosa of rats of both sexes and acanthosis and hyperkeratosis of the limiting ridge observed among male rats. These gastric changes were considered attributable to the irritant nature of the test material formulation and were, therefore, not considered to represent a true systemic effect of treatment. The conditions underwent slight regression in the 1000 mg/kg/day recovery group following 14-days without treatment. These effects were not seen at the next lowest dose concentration of 250 mg/kg/day and this dose was therefore deemed the study NOEL and also the dose level appropriate for determination of the oral DNEL for systemic effects.
The NOEL from the oral 28-day study is the only dose descriptor applicable for DNEL derivation for systemic exposure given it is the only value relating to long-term exposure. Dose descriptors for long-term dermal and inhalation exposure have been extrapolated from this oral endpoint.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.73 mg/m³
DNEL related information
- Overall assessment factor (AF):
- 600
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.84 mg/kg bw/day
DNEL related information
- Overall assessment factor (AF):
- 300
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.84 mg/kg bw/day
DNEL related information
- Overall assessment factor (AF):
- 300
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Discussion as for workers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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