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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 478-200-6 | CAS number: 907606-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Acute Oral)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: Rat (Charles River)
Administration / exposure
- Vehicle:
- other: 1% w/v aqueous methylcellulose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Mortality:
- Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2 - Clinical signs:
- other: Signs of toxicity related to dose levels: Three females dosed at 2000 mg/kg were found dead on Day 2. Clinical signs prior to death comprised hunched posture, piloerection, salivation, unsteady gait, underactivity, and partially closed eyelids seen in
- Gross pathology:
- Effects on organs:
Macroscopic examination of the decedents treated at 2000
mg/kg revealed congestion (characterised by darkened
tissues/organs or blood vessels injected) of the
subcutaneous tissue, brain and heart in all three animals,
and lungs, liver, spleen, stomach, duodenum, caecum, small
and large intestines in two animals. Pallor of the kidneys
was noted in three animals and of the liver and spleen in
one animal. Fluid contents (clear/brown or clear watery
with black specks) were noted in the stomach and duodenum of
three animals and the small intestine of two animals. In
addition, an enlarged/swollen/thickened heart, small
(atrophy) caecum and gaseous distension of the stomach were
also noted in one animal.
Macroscopic examination at study termination on Day 15
revealed pallor of the lungs in two females treated at 300
mg/kg and congestion (darkened tissue/organ) in the spleen
of two animals treated at 2000 mg/kg. No abnormalities were
revealed in any other animal at the macroscopic examination
at this time.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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