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EC number: 402-140-1 | CAS number: 17865-32-6 CHMMS; CHMS; DYNASYLAN 9407; Z-6187
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04.10.1989 to 27.10.1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclohexyldimethoxymethylsilane
- EC Number:
- 402-140-1
- EC Name:
- Cyclohexyldimethoxymethylsilane
- Cas Number:
- 17865-32-6
- Molecular formula:
- C9H20O2Si
- IUPAC Name:
- cyclohexyldimethoxymethylsilane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Ltd
- Age at study initiation: 6-8 weeks (on arrival at lab)
- Weight at study initiation: Approximately 200 g
- Fasting period before study: No
- Housing: Polypropylene cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-24
- Humidity (%): 35-65
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: 04.10.1989 To: 27.10.1989
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: The whole body exposure chambers were of square section and were fitted with pyramidal tops. The chambers were made of perspex.
- Exposure chamber volume: 120 litres
- Method of holding animals in test chamber: Each chamber was divided by wire mesh partitions to provide 10 separate animal compartments.
- Source and rate of air: Described as 'clean, dried air', which was connected to the aerosol generator and the supply pressure was adjusted to give a flow rate of 25 litres/minute measured at the generator outlet tube.
- Method of conditioning air: The compressed air supply to the generator was dried, filtered and oil-free.
- System of generating aerosols: The generator was designed to produce and maintain an atmosphere containing a high proportion of respirable droplets. A flow rate of 0.5 ml/minute test substance to the atomiser was expected to give a concentration of aerosol just in excess of 5 mg/l of air.
- Method of particle size determination: Two samples were taken using a May multistage liquid impinger with acetone/methanol as the trapping agent in each stage (stage 1 - particles >5.5 micrometres; stage 2 - 5.5 to 2.0 micrometres; stage 3 - <2.0 micrometres). The contents of the stages were analysed to determine the particle size distribution in the atmosphere.
- Treatment of exhaust air: Each chamber was positioned inside a large glass walled cabinet equipped with an extractor fan exhausting to atmosphere through a collection filter.
- Temperature, humidity, pressure in air chamber: Approximately 23oC. No data for humidity or chamber pressure.
TEST ATMOSPHERE
- Brief description of analytical method used: Five air samples were taken from the chamber during each exposure and analysed to determine the concentration of test substance. The samples were drawn through an absorption trap, containing approximately 20ml of acetone, at a sampling rate of 2 litres/minute.
- Samples taken from breathing zone: no data
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: 81% in respirable range (<5.5 micrometres) - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.53 mg/l
- No. of animals per sex per dose:
- Five
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed continuously during the exposure period for signs of toxicity, and twice daily during the observation period of 14 days. All rats were weighed daily.
- Necropsy of survivors performed: yes
- Other examinations performed: Food and water consumption was measured by cage. At the end of the observation period a detailed macroscopic examination was conducted. Lungs weights were measured. Lungs, liver and kidneys were examined microscopically.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.53 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No deaths
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: Partial closing of the eyes, hunched/prone posture, wet snout and slow breathing rate were observed, but are considered consistent with exposure to a mildly irritant aerosol. Wet fur, slow breathing rate, staggering and sensitivity to touch were observed,
- Body weight:
- There was an initial loss of weight or reduced bodyweight gain 1 -2 days after exposure. Subsequently, there was no difference between controls and treated animals.
- Gross pathology:
- Lung weights were normal. There were no abnormal macro- or micro-scopic findings.
- Other findings:
- Food consumption was reduced for 1 -2 days following exposure.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In an acute aerosol inhalation study conducted using a protocol comparable to OECD Test Guideline 403 and in compliance with GLP (reliability score 1), the LC50 for cyclohexyldimethoxymethylsilane was greater than 5.53 mg/l in rats (whole-body). Wet fur, slow breathing rate, staggering and sensitivity to touch were observed, but only on the first day. All animals were normal by Day 1 of the observation period. There was an initial loss of weight or reduced bodyweight gain 1 -2 days after exposure. Subsequently, there was no difference between controls and treated animals. Food consumption was reduced for 1 -2 days following exposure. Lung weights were normal. There were no abnormal macro- or microscopic findings.
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