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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19/08/2008-03/07/2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to the OECD guideline and it sis GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Principles of method if other than guideline:
- This method utilizes a high performance liquid chromatograph with UV/VIS and ELSD detector, reversed phase column and an aqueous mobile phase.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- not specified
- Test temperature:
- 25ºC
- Details on study design: HPLC method:
- Apparatus:
Merck-Hitachi Sampler L-7200
Merck-Hitachi Pump L-6200
Sedex ELSD Detector 85
Merck-Hiachi UV/VIS-Detector L-4000
Crococil LCSOF 55
Column:
Luna CN, particle size 5µm, 50 mm x 4.6 mm
Pre-Colimn: CN
HPLC Eluent: Water / Methanol (45:55; v/v); pH 6.06
Detection: Test item: ELSD
Reference items: 220nm
Sodium nitrate: 220 nm
Temperature: 25ºC
Injection Volume: 10µL
Flow: 1.0 mL/min
Run Time: 12 minutes - Analytical monitoring:
- not required
- Details on sampling:
- The substance (58.45mg) was dissolved in methanol (50mL) to prepare a stock solution of 1169µg/mL. The stock solution (5mL) was diluted with a solvent mixture of water and methanol (45:55; v/v) to 10mL to obtain a test item solution of 584.5µg/mL. The pH value of the test item solution was determined to be 6.48. This test item solution was injected three times.
- Type:
- Koc
- Value:
- 6 423
- Type:
- log Koc
- Value:
- 3.8
- Validity criteria fulfilled:
- yes
- Conclusions:
- The log of the adsorption coefficient (Koc) of the substance was calculated to be logKoc=3.8 which is equal to a Koc value of 6423 using the HPLC method. This value indicates that the susbtance is immobile.
- Executive summary:
The determination of the adsorption coefficient (KOC) of AA 15 was performed according to the OECD Guideline for the Testing of Chemicals, No.121, Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), January, 2001 and the EC Directive 2001/59, C.19.
The detection of the reference items were performed using UV detection. Isoproturon, pyrazophos and diclofop-methyl were detectable using ELSD. The substance was not detectable using UV detection. Therefore, the test item was measured using ELSD.
The chromatography of the test item resulted in one main peak with a well-defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, the substance was considered to be stable during the test procedure.
The log of the adsorption coefficient (Koc) of the substance was calculated to be logKoc = 3.8 which is equal to a Koc value of 6423 using the HPLC method. Because of the high Koc value of the substance it can be said thar the test item is immobile in organic matter.
This study is considered as relevant. All the validity criteria were fulfilled and no deviations were observed from the OECD 301B guideline.
Reference
Description of key information
The determination of the adsorption coefficient (KOC) of AA 15 has been investigated in a study according to the OECD Guideline for the Testing of Chemicals, No.121, Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), January, 2001 and the EC Directive 2001/59, C.19. This study was assessed as a key study.
The log of the adsorption coefficient (Koc) of the substance was calculated to be logKoc = 3.8 at 20°C which is equal to a Koc value of 6423 using the HPLC method.
Because of a Koc value > 5000, the substance test item is considered immobile in organic matter according to McCall et al. (1980) scale of mobility classes.
Key value for chemical safety assessment
- Koc at 20 °C:
- 6 423
Additional information
The determination of the adsorption coefficient (KOC) of AA 15 was performed according to the OECD Guideline for the Testing of Chemicals, No.121, Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), January, 2001 and the EC Directive 2001/59, C.19.
The detection of the reference items were performed using UV detection. Isoproturon, pyrazophos and diclofop-methyl were detectable using ELSD. The substance was not detectable using UV detection. Therefore, the test item was measured using ELSD.
The chromatography of the test item resulted in one main peak with a well-defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, the substance was considered to be stable during the test procedure.
The log of the adsorption coefficient (Koc) of the substance was calculated to be logKoc = 3.8 which is equal to a Koc value of 6423 using the HPLC method. Because of the high Koc value of the substance it can be said thar the test item is immobile in organic matter.
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