Registration Dossier
Registration Dossier
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EC number: 206-337-1 | CAS number: 328-84-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No studies on the skin sensitizing potential of 3,4-dichloro-α,α,α-trifluorotoluene were available. However, Article 13 of REACH states that, in case no appropriate animal studies are available for assessment, information should be generated whenever possible by means other than vertebrate animal tests, i.e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across.
One report (BG Chemie Toxikologische bewertungen, Nr. 89, 1997) is available in which the result of a skin sensitisation study is presented of the structural analogue 3-chloro-α,α,α-trifluorotoluene. It was stated that 3-chloro-α,α,α-trifluorotoluene was not sensitizing to the skin in guinea pigs.
Justification for classification or non-classification
3,4-dichloro-α,α,α-trifluorotoluene is suspected to have a similar skin sensitizing potential as 3-chloro-α,α,α-trifluorotoluene, because is it a structural analogue. Based on this classification for both skin sensitization is not warranted in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substance and Mixtures (CLP) Regulation No. 1272/2008.
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