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EC number: 203-526-0 | CAS number: 107-85-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In valid acute toxicity rat studies, the LD50 was 341 and 427 mg/kg bw (oral) and 2000 mg/kg bw (dermal), respectively. The inhalation LC50(rat, 4 hr) was 11,500 mg/m³. Toxicity and mortality was closely related to the corrosivity of isopentylamine on either route of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 341 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 11 500 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute oral toxicity of 3-methylbutylamine was tested in male and female Wistar rats (n=5/sex and dose; dose levels 63, 100, 160, 250, 315, 400, and 630 mg/kg bw (each 5 % (w/v) in water); oral gavage) in a study that was conducted according to OECD TG 401 and under GLP conditions. Mortality occurred within few days. Necropsy revealed corrosion of the GI tract (stomach, gut) and corrosion and adhesion of inner organs (liver, pancreas, kidneys).The LD50 was 427 mg/kg bw in male and female rats in this study (Hoechst, 1985). In another study (Wistar rats, 5/sex; doses 215, 464, 1000 mg/kg bw) a slightly lower LD50 value (341 (range 251 -460) mg/kg bw) was determined (BASF, 1987).
The acute inhalation toxicity of isopentylamine was examined in male and female rats (n=5 per sex and dose) that were exposed to isopentylamine (duration 4 hours; 5.2, 9.9, and 17.4 mg/L; analytical monitoring) in a guideline study under GLP conditions. The observation period was 14 days.
Signs of eye and respiratory irritation were seen during exposure at all concentrations. Mortalities occurred at all dose levels on the day of exposure. Body weight of survivors was reduced in the first week after treatment, but was comparable to historical controls at the end of the second week. Gross pathology revealed general congestion and hyperemia of the lungs at all dose levels. The combined male and female LC50(rat, 4 hr)was 11.5 mg isopentylamine/L (11,500 mg/m³) in this study. Local irritation (includes respiratory tract) was considered to cause toxicity and mortality (BASF, 1989).
The acute dermal toxicity was tested according to the OECD TG 402 and under GLP conditions. 5 male and female Sprague-Dawley rats received 2000 mg/kg bw of 3-methylbutylamine (50% in water), and the animals were observed until the end of the 14-day observation period. No systemic toxicity was seen in any rat. However, 5 of 10 animals were killed for humane reasons (one male on day 10; four females on days 7-10), based on the poor state of the skin. In the preliminary study, skin corrosion had been seen in all animals treated with the neat substance at 2000 mg/kg bw. In an attempt to reduce the local effects, a 50% solution of the amine in water was used in the definitive study, which, however, resulted also in skin corrosion.
Based on the above, the acute dermal LD50 value is 2000 mg/kg bw in the rat (Safepharm, 1985).
Justification for classification or non-classification
Acute toxic properties of isopentylamine require classification as tabulated below.
Route |
Effect level |
value |
Regulation 67/548/EC |
Regulation 1272/2008/EC |
oral |
LD50, rat |
341 mg/kg bw |
Xn, R25 |
Acute tox, cat 4 |
inhalation |
LC50, rat, 4 hrs |
11.5 mg/L |
Xn, R20 |
Acute Tox, cat 4 |
dermal |
LD50, rat |
2000 mg/kg bw |
Xn, R 21 |
Acute Tox, cat 4 |
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