Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Principles of method if other than guideline:
- Test was done according to the method of E.J. de Beer ( Journal of Pharmacology and Experimental Therapeutics, 85:1, 1945
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Reference substance name:
- Mercaptobenzothiazole
- IUPAC Name:
- Mercaptobenzothiazole
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 3160, 3980, 5010, 6310 mg/kg
- No. of animals per sex per dose:
- 4 groups of 5 (mix of M&F)
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 800 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 530 - 4 100
- Mortality:
- dose 3980mg/kg: 3 deaths
doses 5010 and 6310 mg/kg: 5 deaths - Clinical signs:
- Reduced appetite and activity (1 to 3 days in survivors), increasing weakness, collapse and death
- Gross pathology:
- Lung hypermia, slight liver discoloration, and gastrointestinal inflammation.
Viscera of surviving animals appeared normal at sacrifice.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 was 3800 mg/kg (95% confidence limits 3530-4100 mg/kg)
- Executive summary:
The aim of the study was to determine the acute oral toxicity due to the test material in Sprague-Dawley albino rats ( 4 groups of 5 (mix of M&F). The oral LD50 was 3800 mg/kg (95% confidence limits 3530-4100 mg/kg).
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