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Diss Factsheets
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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on generations indicated in Effect levels (migrated information)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from review article (report on chlorophenols - systematic review and critical evaluation of relevant data). Basic data given.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
- Reference Type:
- review article or handbook
- Title:
- Chlorophenols other than pentachlorphenol (environmental health criteria 93)
- Author:
- EHC
- Year:
- 1 989
- Bibliographic source:
- http://www.inchem.org
- Reference Type:
- publication
- Title:
- Toxicity of 2-chlorophenol, 2,4-dichlorophenol, and 2,4,6-trichlorophenol.
- Author:
- Exon JH, Koller LD
- Year:
- 1 985
- Bibliographic source:
- In: Jolley, R.L, Bull, R.J., Davis, W.P., Katz, S., Roberts, M.H., Jr, & Jacobs, V.H., ed. Water chlorination: Environmental impact and health effects, Chelsea, Michigan, Lewis Publishers Inc., Vol. 5, pp. 307-330.
- Reference Type:
- publication
- Title:
- Alteration of transplacental carcinogenesis by chlorinated phenols.
- Author:
- Exon JH, Koller LD
- Year:
- 1 981
- Bibliographic source:
- In: Jolley, R.L., Brungs, W.A., Cotruvo, J.A., Cumming, R.B., Mattice, J.S., & Jacobs, V.A, ed. Water chlorination: Environmental impact and health effects, Ann Arbor, Michigan, Ann Arbor Science Publishers, Vol. 4, Book 2, pp. 1177-1188.
Materials and methods
- Principles of method if other than guideline:
- Reproductive toxicity study - (long-term) oral exposure
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-MCP
- IUPAC Name:
- 2-MCP
- Reference substance name:
- 2-chlorophenol
- EC Number:
- 202-433-2
- EC Name:
- 2-chlorophenol
- Cas Number:
- 95-57-8
- IUPAC Name:
- 2-chlorophenol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- ca. 6 months (pre-and postnatal exposure of progeny)
- Details on study schedule:
- Dams were exposed from 3 weeks of age through gestation gestation (bred at day 90 d) and lactation (12-14/group).
The progeny from each dose regime was continued on treatment from three weeks of age (weaning) until tumour development, death or termination of the study at 24 months (24-28 animals of each sex/group).
Eight randomly selected pups from each group were weaned at 3 weeks of age and continued on treatment for 10-15 weeks.
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
500 mg/L
Basis:
nominal in water
(equivalent to 50 mg/kg bw/d)
- Remarks:
- Doses / Concentrations:
50 mg/L
Basis:
nominal in water
(equivalent to 5 mg/kg bw/d)
- Remarks:
- Doses / Concentrations:
5 mg/L
Basis:
nominal in water
(equivalent to 0.5 mg/kg bw/d)
- Control animals:
- yes, concurrent vehicle
- Positive control:
- Not applicable.
Examinations
- Parental animals: Observations and examinations:
- BODY WEIGHT: Yes
- Time schedule for examinations: Body weight gain prior to breeding
OTHER:
- Maternal toxicity (body weight gain prior to breeding) - Litter observations:
- REPRODUCTIVE PERFORMANCE
- conception
PARAMETERS EXAMINED
The following parameters were examined in F1 offspring:
- litter size [live and stillborn]
- number of of stillborn
- birth weight
- survival to weaning
- weaning weight - Postmortem examinations (offspring):
- SACRIFICE / EFFECT ON THE PROGENY
- body weight gain
- weight of thymus
- spleen and liver at termination
- haematology (red and white blood cell counts, packed cell volume, mean corpuscular volume, haemoglobin)
- immunocompetence (cell-mediated immunity, humoral immunity, number and phagocytic activity of peritoneal macrophages) at termination
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEL
- Remarks:
- maternal
- Effect level:
- 50 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: No maternal toxicity.
- Dose descriptor:
- NOAEL
- Remarks:
- reproduction
- Effect level:
- 5 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Litter size decreased and the number of stillborn increased at 500 mg/L.
Results: F1 generation
Details on results (F1)
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 5
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: After 52 weeks: Increased red blood cell count, packed cell volume, and haemoglobin content.
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
However, according to ATDR (1999), there is limited evidence that 2 -chlorophenol may reduce litter sizes when administered to rats in drinking water (Exon and Koller 1985).This effect was significant only at p≤0.1 and was observed at doses that caused other effects (e.g., increased liver weights, decreased delayed-type hypersensitivity).
Reference: ATDR, 1999. Toxicological profile for Chlorophenols, U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, July 1999, p. 126. [external reference]
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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