Registration Dossier
Registration Dossier
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EC number: 270-126-0 | CAS number: 68411-44-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
In accordance with the CLP Regulation criteria, a substance is classified as to its acute oral toxicity if LD50≤2 000 mg/kg bw. The published data on acute oral toxicity of butylbenzene components is above the cut off value of 2000 mg/kg bw for classification.
Additionally, QSAR model Toxtree, v. 2.1.0 based on Estimation of Toxic Hazard –A Decision Tree Approach classifies butylbenzene components as Class I Low Toxic Hazard Chemical.
It is, therefore, considered that butylbenzene is of low acute toxicity in experimental animals by oral exposure route.
However, based on the data on viscosity of butylbenzene components, it is considered that swalloing the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis. Butylbenzene is, therefore, classified asAspiration hazard: Asp. Tox. 1; H304: May be fatal if swallowed and enters airways.
The cut-off value for classification of substances for acute inhalation toxicity for vapours is LC50= 20 mg/L and for mists/aerosols LC50=5 mg/L The published data for butylbenzene components report LC50 values which correspond to Acute Tox. 4; H332: Harmful if inhaled. In addition, ethylbenzene, the closest structural analogue of butylbenzene, is also classified as acute toxicity by inhalation Category 4.
Thus, butylbenzene is classified as Acute toxicity - inhalation: Acute Tox. 4; H332: Harmful if inhaled, according to the GHS criteria of Regulation (EC) No 1272/2008 (self classification) and Acute toxicity: Xn; R20 Harmful; Harmful by inhalation, according to the DSD/DPD criteria of Annex I of Directive 67/548/EEC (self classification).
Given its physico-chemical properties (i.e. high volatility, high flammability) it will be difficult to perform the test on butylbenzene using standard test requirements for acute dermal toxicity testing.
The cut-off value for classification of substances for acute dermal toxicity is LD50= 2000 mg/kg. The published data for butylbenzene components report LD50 values higher than the cut off for classification.
It is, therefore, considered that butylbenzene is of low acute toxicity in experimental animals by dermal exposure.
Justification for classification or non-classification
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