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Diss Factsheets
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EC number: 800-766-3 | CAS number: 1424148-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1991-03-04 to 1991 03-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Rationale for the reliability: Guideline study; well-performed and well-documented; read-across Rational for the justification: the grouped substances differ only that the read-across substance is a weak acid and that the registration substance is the corresponding salt. When dissolved in biological fluid, the regitration substance will be converted to the read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (Pentapropylensuccinimido)-caproic acid
- IUPAC Name:
- (Pentapropylensuccinimido)-caproic acid
- Reference substance name:
- 6-[3-(C14-C18)-alkenyl(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid
- EC Number:
- 800-767-9
- Cas Number:
- 1424148-94-6
- Molecular formula:
- C22H37NO4 - C28H49NO4
- IUPAC Name:
- 6-[3-(C14-C18)-alkenyl(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Preliminary study; for each dose levels of 500, 1000 and 2000 mg/kg bw one male and one female rats were used. No significant effects were found.
Results and discussion
- Preliminary study:
- No effect found
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality found
- Clinical signs:
- Within 24 hours: increased respiration rate, squatting posture, sunken flanks, stilted and uncordinated gait, decreased spantaenous activity, bristling coat
After 24 hours - Body weight:
- Not impaired in the observation period of 14 days
- Gross pathology:
- No effect
Any other information on results incl. tables
Justification for the read-across using (Pentapropylensuccinimido)-caproic acid as supporting substance.
The read-across supporting substance is a weak acid and the registration substance is the corresponding weak base. When dissolved in aqueous system or in the biological fluid the registration substance will be dissociated and converted in the read-across supporting substance and sodium ion/triethanolamine ammonium, thereby explaning the expected comparability. The counter ions of the registration substance, sodium ion and triethanolammonium ions are of limited toxicological meaning for the endpoint acute toxicity.
Upon exposure to the registration substancel the conversion to the read-across supporting substance is likely to occur prior to adsorption. It means, the conversion occurs mostly already in the gastro-intestinal tract, in the fluid of the respiratory tract and during the penetration of the upper layer of epidermis for uptake routes oral, inhalative and dermal respectively.
It is therefore apparent that there should be no potency difference on bases of molar dose. For obtaining the proper LD50 for the registration substance, the only factor to be considered is the molecular mass difference (530 g/mol vs ca. 420 g/mol).
The provided dose level of 2000 mg/kg bw of the read-across supporting substance corresponds to 2500 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity of the read-across supporting substance was investigated according to the OECD Guideline 401. At dose of 2000 mg/kg bw no significant effect was found.
- Executive summary:
The acute oral toxicity of the read-across supporting substance was investigated according to the OECD Guideline 401. At dose of 2000 mg/kg bw no significant effect was found. The doses provided equals 2500 mg/kg bw of the registration substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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