Registration Dossier
Registration Dossier
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EC number: 204-658-1 | CAS number: 123-86-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study performed according to guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to B Ames et al. (1975) Mutat Res 31:347-364
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538; Escherichia coli WP2 uvrA
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 1 - 5000 ug/plate
- Species / strain:
- other: TA 98, TA 100, TA 1535, TA 1537, TA 1538; Escherichia coli WP2 uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Conclusions:
- Interpretation of results (migrated information):
negative
negative
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
all listed studies show negative results.
Justification for selection of genetic toxicity endpoint
best available data
Justification for classification or non-classification
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