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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-661-7 | CAS number: 67-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Development and Validation of an Alternative Dermal Sensitization Test : The Mouse Ear Swelling Test (MEST)
- Author:
- Gad S.C., Dunn B.J., Dobbs D.W., Reilly C., Walsh R.D.
- Year:
- 1 986
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 84, 93-114.
Materials and methods
- Principles of method if other than guideline:
- Not reported
- GLP compliance:
- no
- Type of study:
- mouse ear swelling test
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- propan-1-ol
Analytical purity: > 98 %.
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- female
- Details on test animals and environmental conditions:
- - Age at study initiation: 6-8 weeks
- Housing: 5/cage
- Diet: ad libitum, (Purina Rodent Laboratory Chow 5001)
- Water: ad libitum
- Aclimation: 7 days (during this period, any animal with red or swollen ear disqualified and was removed from the study)
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Induction: 100%
Challenge: 100%
Basis of selection: Based on solubility of n-propanol
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Induction: 100%
Challenge: 100%
Basis of selection: Based on solubility of n-propanol
- No. of animals per dose:
- Test groups: 10
Irritation control: 5 - Details on study design:
- PRELIMINARY RANGE FINDING TEST
- Number of animals: 2/concentration
- Induction: procedure as described in main study whereby four concentrations were used for induction; no further information
- Challenge: each group was challenged at a different concentration; no further details given
- Evaluation: 24 h after challenge
Results: Concentrations utilized in the main study was the highest with minimal iiritation or non-iiritating to the stomach (for induction) and nonirritating to the ear (for challenge)
MAIN STUDY
IRRITATION CONTROL ANIMALS
INDUCTION EXPOSURE:
- Site of application: Abdomen
- Shaved: yes, before application on Day 0
- FCA (Freund's Complete Adjuvant) pretreatment: Yes, injected intradermally 2x á 0.05 ml after which the abdominal skin was then tape stripped.
- Volume: it is unclear from reporting if control animals were induced with a control substance or not, since test substance was applied undiluted (unchanged)
- Repeation: Yes, tape stripping and topical induction applications were repeated for additional 3 consecutive days
CHALLENGE
- Time schedule: 7 days after induction
- Area of application: left ear, (test substance); right ear (treatment unclear; untreated or if treated what solvent was employed)
- Volume applied: 20 µl
- Concentration: undiluted (100%)
- Evaluation: 24h and 48h after challenge
- Anesthesia: Yes, ether before measurement
TEST GROUP
INDUCTION EXPOSURE:
- Site of application: Abdomen
- Shaved: yes, before application on Day 0
- FCA (Freund's Complete Adjuvant) pretreatment: Yes, injected intradermally 2x á 0.05 ml after which the abdominal skin was then tape stripped.
- Volume (Test substance): 100µl applied topically to the center of the shaved region. Area dried with electric dryer
- Concentration: undiluted (100%)
- Repeation: Yes, tape stripping and topical induction applications were repeated for additional 3 consecutive days
CHALLENGE
- Time schedule: 7 days after induction
- Area of application: left ear, (test substance); right ear (treatment unclear; untreated or if treated what solvent was employed)
- Volume applied: 20 µl
- Concentration: undiluted (100%)
- Evaluation: 24h and 48h after challenge
- Anesthesia: Yes, ether before measurement - Positive control substance(s):
- yes
- Remarks:
- Ethylene diamine, dinitrochlorobenzene and p-phenylenediamine
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- Induction 100%; challenge 100%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: Induction 100%; challenge 100% . No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: no data.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- Induction 100%; challenge 100%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no data
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: Induction 100%; challenge 100% . No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: no data.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- not sensitising
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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