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EC number: 696-318-8 | CAS number: 174489-43-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- prop-2-en-1-yl 2-(5-amino-2-chlorobenzoyloxy)-2-methylpropanoate
- EC Number:
- 696-318-8
- Cas Number:
- 174489-43-1
- Molecular formula:
- C14H16ClNO4
- IUPAC Name:
- prop-2-en-1-yl 2-(5-amino-2-chlorobenzoyloxy)-2-methylpropanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BRL Biological Research Laboratories, Wölferstrasse 4, 4414 Füllinsdorf / Switzerland
- Age at study initiation: Young adult (approximately 7 - 11 weeks).
- Weight at study initiation: 172 - 230 g
- Fasting period before study: Prior to dosing, the animals were fasted overnight.
- Housing: Three same sex animals per cage.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 50 % ± 20 %
- Air changes (per hr): 13-14/hour
- Photoperiod (hrs dark / hrs light): 12/12 hours
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5 % (w/v) in 0.1 % aqeuous polysorbate 80
- Details on oral exposure:
- - Dose level: 200 mg/kg (females), 2000 mg/kg (both sexes)
- Number of animals per dose level: 3 males and 3 females (2000 mg/kg)
3 females (200 mg/kg)
- Vehicle: 0.5% (w/v) CMC (carboxy methyl cellulose) in 0.1% (w/v) aqueous polysorbate 80.
- Concentration: 200 mg/kg: 201 mg test item with vehicle ad 10 ml
2000 mg/kg: 2025 mg test item with vehicle ad 10 ml
2000 mg/kg: 1993 mg test item with vehicle ad 10 ml
- Volume applied: 10 ml/kg
- Rationale for the selection of the starting dose: The dose level was selected based on EU classification criteria and pre-test results. - Doses:
- One single dose
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Period of observation: 14 days.
- Clinical observations: Checked and recorded individually at 1, 3 or 4 and 5 hours after dosing, then daily for the duration of the observation period.
- Mortality: Checked twice daily, morning and afternoon.
- Body weight: Measured and recorded immediately before dose administration, then on days 7 and 14.
Results and discussion
- Preliminary study:
- The dose level of 2000 mg/kg was selected based on EU classification criteria and pre-test results.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortality in the study.
Threrefore, the following acute oral LD50 values were determined for CA 2219 A (Intermediate CGA 276854):
LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight - Clinical signs:
- other: There were no in-life observations indicating treatment-related systemic effects for any animal.
- Gross pathology:
- Necropsy examinations revealed no observable abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
The following acute oral LD50 values were determined for CA 2219 A Intermediate of CGA 276854):
LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight- Executive summary:
Groups of 3 male and 3 female rats were administered a single dose of CA 2219 A (Intermediate CGA 276854) (batch no. 249-GE001/SU) by gavage at a dose levels of 200 mg/kg (females) and 2000 mg/kg (both sexes), followed by a 14 day post-treatment observation period.
There was no mortality in the study.
There were no in-life observations indicating treatment-related systemic effects for any animal.
Body weights were not affected by the treatment.
Necropsy examinations revealed no observable abnormalities.
The following acute oral LD50 values were determined for CA 2219 A Intermediate of CGA 276854):
LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight
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