Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 250-284-7 | CAS number: 30674-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study predates the appropriate OECD test guideline and GLP. Although not in accordance with recent guideline (only 2 animals tested, of which one reveived an eye wash) the study is sufficient for assessment as the observations were severe enough for a classification as severe eye irritant (worst case outcome).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 mL of undiluted test material was instilled into the conjunctival sac of each of two albino rabbits. After 20 s, the treated eye of one animal was washed for 1 min. Following treatment for 4 h, the eye damage was examined.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-isocyanatoethyl methacrylate
- EC Number:
- 250-284-7
- EC Name:
- 2-isocyanatoethyl methacrylate
- Cas Number:
- 30674-80-7
- Molecular formula:
- C7H9NO3
- IUPAC Name:
- 2-isocyanatoethyl methacrylate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No details are given in the study report.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- 4 h
- Observation period (in vivo):
- 21 d
- Number of animals or in vitro replicates:
- 21
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: the eye of one animal was washed with tap water for 1 min
- Time after start of exposure: 20 s after test material instillation
SCORING SYSTEM: No scores were given in the study report.
TOOL USED TO ASSESS SCORE: hand-slit lamp / fluorescein
Results and discussion
In vivo
Results
- Remarks on result:
- other: No scores were given in the study report.
- Irritant / corrosive response data:
- Animal 12101 (without washing):
- Cornea: slight opacity, where seen, 1-4 h; slight generalised opacity with severe swelling 1-2 days; generalised opacity increasing from mild to moderate 3-14 days, swelling of cornea severe; extensive, very fine, dense superficial vascularisation penetrating into cornea by 14 days with an ulcer in the centre. At 21 days, pannus with some areas staining yellow (still active ulcer)
- Iris: could not see 1-4 h; slight injection (no flare) 1 day; swelling and deepened folds (no redness) 2-3 days; could not see 7 days; moderate congestion 9 days; could not see 14 or 21 days
- Conjunctivae (redness): severe blanching, mild redness 1-4 h; moderate with necrotic area and haemorrhage 1-3 days; severe to moderate 7, 9, and 14 days; moderate 21 days
- Conjunctivae (swelling): severe 1 h-14 days; by 7 days there were adhesions of tissues and eye could not be opened. At 9 days using a local anaesthetic and "Q-tips" these adhesions were separated, somewhat. Swelling remained severe but eye could be partly opened. Mild to moderate 21 days.
Conjunctivae (discharge): copious 1-4 h; copious purulent, Hemastix positive 1 day; moderate purulent 3-7 days; moderate purulent (becoming bloody) 9 days; moderate purulent 14 days; mild purulent 21 days
Animal 12102 (with washing):
- Cornea: mild opacity. where seen 1-4 h; generalised mild to moderate opacity with moderate to severe swelling 1-14 days; vascularisation began penetrating (shallow type) into cornea by 7 days with an area in central cornea staining yellow (an ulcer). By 14 and 21 days pannus over > 3/4 of cornea with active ulcer in center.
- Iris: could not see 1-4 h; moderate congestion (no flare) 1 day; moderate congestion with flare 2-3 days; moderate congestion 7 days but too opaque to see a flare
- Conjunctivae (redness): severe blanching with mild redness 1-4 h; moderate to severe 2-7 days; mild 14 and 21 days
- Conjunctivae (swelling): severe 1 h-1 day; moderate 2-7 days; slight 14 and 21 days
- Conjunctivae (discharge): copious 1-4 h; copious purulent 1-3 days; mild purulent 7 days; none 14 days; mild purulent 21 days
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS Category 1 (H318) according to Regulation (EC) No 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.