Propionyl chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propionyl chloride

EC Number:

201-170-0

EC Name:

Propionyl chloride

Cas Number:

79-03-8

Molecular formula:

C3H5ClO

IUPAC Name:

propanoyl chloride

Details on test material:

- Name of test material (as cited in study report): propionylchlorid
- Substance number.: 79/618

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source:HAGEMANN+WIGA
- Fasting period before study: 15 - 20 h before application
- Diet: HERILAN MRH-HALTUNG; H. EGGERSMANN KG

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

Details on oral exposure:

Application volume: 5 ml/kg bw

Doses:

215, 464, 562, 681, 825 and 1000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

Finney, D .J ., Probit Analysis, Cambridge University Press, 3 . Aufl., 1971

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

823 mg/kg bw

Based on:

test mat.

95% CL:

731 - 990

Mortality:

215 and 464 mg/kg bw: no deaths after 14 days
562 mg/kg bw: 2/5 males and 0/5 females after 14 days
681 mg/kg bw: 1/5 males and 0/5 females after 14 days
825 mg/kg bw: 3/5 males and 2/5 females after 14 days
1000 mg/kg bw: 4/5 males and 4/5 females after 14 days

Clinical signs:

other: Dyspnea, apathy, abnormal position, staggering, atony, shivering, spastic walk, ragged skin, exsiccation, paresis (these effects were predominantly oberved at 825 and 1000 mg/kg bw).

Gross pathology:

Diseased animals: acute dilatation of the heart, acute congestive hyperemia, mordant gastritis, enteritis, diarrhea, liver dystrophy
Euthanized animals: stomach wall thickened, scattered aggregation of stomach and spleen with the peritoneum