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EC number: 273-321-9 | CAS number: 68956-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- please refer to the field "Principle of method if other than guideline"
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- please refer to the field "Principle of method if other than guideline"
- Principles of method if other than guideline:
- - Test was conducted under exclusion of carbon dioxide and oxygen, to avoid oxidative degradation of the organic anion.
- Two vessels were set up in a parallel design at 20 ± 1.0 °C, each vessel was sampled several times instead of sampling one vessel at every point in time, to reduce the weighing error. - GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2011-02-07
- Type of method:
- flask method
- Water solubility:
- >= 27.06 - <= 30 mg/L
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 6.7
- Remarks on result:
- other: dissolved cobalt resinate
- Water solubility:
- >= 1.96 - <= 2.532 mg/L
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 6.7
- Remarks on result:
- other: dissolved Co
- Details on results:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert argon gas; flask method; loadings of 350.6 g/L in vessel A and B, respectively), a solubility equilibrium was reached during the three days of testing (days 3 – 5). The mean amount of dissolved cobalt during the test at 20.0 ± 1.0°C is 2.246 ± 0.286 mg/L (determined as dissolved Co, separated by filtration from undissolved test item). This corresponds to dissolved cobalt resinate of 28.08 ± 1.02 mg/L. After adding the test substance the pH in the respective vessels decreased slightly from 6.9 to 6.2 in vessel A and from 6.6 to 6.1 in vessel B. Measured pH blank samples were between 6.4 and 6.7.
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
Under the conditions of this test (under exclusion of CO2 and O2, under inert argon gas; flask method; loadings of 350.6 g/L in vessel A and B, respectively), a solubility equilibrium was reached during the three days of testing (days 3 – 5) the water solubility of cobalt resinate is 28.08 ± 1.02 mg/L at pH 6.4 - 6.7. - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-07-30 to 2009-08-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- , 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- , 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2008-11-12
- Type of method:
- flask method
- Water solubility:
- 33.53 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 6.79
- Water solubility:
- 272.89 mg/L
- Temp.:
- 37 °C
- pH:
- ca. 6.58
- Details on results:
- During this study the water solubility of cobalt resinate at 20 °C and at 37 °C was determined using the flask method and was found to be 33.53 mg/L at 20 °C (after 120 hours of shaking) based on a measured concentration of 2.57 mg Co/L and 272.89 mg/L at 37 °C (after 120 hours of shaking) based on a measured concentration of 20.88 mg Co/L.
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
During this study the water solubility of cobalt resinate at 20 °C and at 37 °C was determined using the flask method and was found to be 33.53 mg/L at 20 °C based on a measured concentration of 2.57 mg Co/L and 272.89 mg/L at 37 °C based on a measured concentration of 20.88 mg Co/L.
Referenceopen allclose all
Method validation summary
Validation parameter |
results |
comment |
selectivity |
similar data with three different cobalt wavelengths for ICP-OES method |
no matrix effects observed |
linearity |
applied calibration functions were linear |
correlation coefficient at least 0.9992 |
limit of detection (LOD) |
20 - 25 µg Co/L |
|
limits of quantification (LOQ) |
66 - 83 µg Co/L |
|
method blanks |
below LOD (< 25 µg Co/L) |
- |
accuracy and precision |
mean recovery for TMDA-70: |
corresponds to concentration range of diluted samples |
accuracy and precision |
mean recovery for CPI quality control standard: |
corresponds to concentration range (250 µg Co/L) |
accuracy and precision |
mean recovery for CPI quality control standard: |
corresponds to higher concentration range (500 µg Co/L) |
accuracy and precision |
mean recovery for recalibration standards: |
corresponds to lower concentration range (100 µg Co/L) |
repeatability |
recovery from fortification of samples: 99.3 – 101 % (n=4) |
|
reproducibility |
mean recovery for TMDA-70: |
corresponds to concentration range of diluted samples (285 µg Co/L) |
reproducibility |
mean recovery for CPI quality control standard: |
corresponds to concentration range (250 µg Co/L) |
Measured cobalt concentrations in test samples
stirring |
Co conc. of samples |
mean Co |
Co conc. of samples |
mean Co |
mean Co |
variation between samplings |
3 |
1.684 |
1.694 ± 0.014 |
2.342 |
2.342 ± < 0.001 |
2.018 ± 0.374 |
- |
1.704 |
2.342 |
|||||
4 |
2.137 |
2.146 ± 0.013 |
2.478 |
2.491 ± 0.018 |
2.318 ± 0.199 |
14.9 |
2.155 |
2.503 |
|||||
5 |
2.297 |
2.312 ± 0.021 |
2.487 |
2.495 ± 0.011 |
2.403 ± 0.106 |
3.7 |
2.326 |
2.502 |
The shaking flask vessels were set up in duplicate. Samples were taken after 3 (72), 4 (96), and 5 days (120 hours). The pH was measured in the test vessels and Co concentrations as well as the turbidity were determined in samples after filtration. After adding the test substance the pH in the respective vessels decreased slightly from 6.9 to 6.2 in vessel A and from 6.6 to 6.1 in vessel B. Measured pH in blank samples were between 6.4 and 6.7. The oxygen concentration inside the experimental setup remained around 0 %.
Co analysis was carried out via ICP-OES. The samples were measured in duplicate. Based on previous test results 175 mg of the test substance was added into 500 mL of argon saturated water under argon atmosphere (175.3 mg/500 mL were weighed into vessel A and B, respectively). This loading corresponded to approx. five to ten times the quantity of the dissolved test item as determined in the previous test. Furthermore insoluble residues in the test vessels were observed throughout the test.
Constant Co concentrations could be measured during the test between days 3 and 5. The variations between the three sampling points were less than 15 %. Thus, the validity criteria as foreseen in OECD TG 105 and Regulation 440/2008/EC A.6 were fulfilled.
The mean dissolved cobalt concentration
between day 3 and day 5 are as follows:
Vessel A: 2.051± 0.286 mg/L
Vessel B: 2.442 ± 0.078 mg/L
The calculated amount of cobalt resinate dissolved was calculated by:
= mean of measured values * 100 % / 8.0 % [percentage of Co in test item]
mean calculated cobalt resinate dissolved day 3 – day 5:
Vessel
A: 25.63 ± 1.12 mg/L
Vessel B: 30.53 ± 0.26 mg/L
Description of key information
Water solubility of resin acids and rosin acids, cobalt salts : 33.53 mg/L at 20 °C, 272.89 mg/L at 37 °C (under oxic atmosphere) and 28.1mg/L (at 20°C under inert gas atmosphere).
Key value for chemical safety assessment
- Water solubility:
- 33.53 mg/L
- at the temperature of:
- 20 °C
Additional information
In Tobler (2009) the water solubility of resin acids and rosin acids, cobalt salts was determined according to OECD guideline 105 with the flask method. During this study the water solubility of the test item was found to be 33.53 mg/L at 20 °C (after 120 hours of shaking) based on a measured concentration of 2.57 mg Co/L and 272.89 mg/L at 37 °C (after 120 hours of shaking) based on a measured concentration of 20.88 mg Co/L.
To assess whether the oxic atmosphere interferes with the water solubility testing a second experiment was conducted under inert gas atmosphere. In Klawonn (2012) a solubility equilibrium was reached during the three days of testing (days 3 – 5) the water solubility of cobalt resinate is 28.08 ± 1.02 mg/L at pH 6.4 - 6.7.
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