Registration Dossier
Registration Dossier
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EC number: 247-891-4 | CAS number: 26658-19-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Daphnia magna (Circular on Test Methods of New Chemical Substances (Japan)); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Sorbitan tristearate (CAS 26658-19-5) to aquatic invertebrates. The assessment was, therefore, based on a study conducted with the structurally similar category member Sorbitan stearate (CAS No. 1338-41-6). This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Sorbitan tristearate and Sorbitan stearate are both Sorbitan esters of saturated C18 fatty acids. Since the Sorbitan stearate mainly consists of monoesters, it can be considered a worst case read-across to Sorbitan tristearate, which is expected to be less bioavailable due to its molecular size (MW 879-982).
The key study conducted with Sorbitan stearate (CAS No. 1338-41-6) was performed according to the Circular on Test Methods of New Chemical Substances (Japan), (Ministry of the Environment, Japan, 2006). The test organism Daphnia magna was exposed to the test substance in a static system for 48 hours, at nominal test concentrations of 100, 180, 320, 560 and 1000 mg/L. No immobilisation was observed at any of the test concentrations, and the LC50 was reported to be above 1000 mg/L.
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