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EC number: 212-092-1 | CAS number: 762-12-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2 july 1998 to 16 july 1998
- Reliability:
- 1 (reliable without restriction)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bisdecanoyl peroxide
- EC Number:
- 212-092-1
- EC Name:
- Bisdecanoyl peroxide
- Cas Number:
- 762-12-9
- Molecular formula:
- C20H38O4
- IUPAC Name:
- decanoyl decaneperoxoate
- Test material form:
- solid: compact
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Crédo, 69210 L'Arbesle, France.
- Age at study initiation: approximately 8 weeks old.
- Weight at study initiation: mean body weight of 253 +/- 12 g for males, and 234 +/- 4 g for females.
- Housing: during the acclimatization periode, four to sevens animals of the same sex were housed in polycarbonate cages.
during the treatment period, the animals were housed individually in polycarbonate cages.
- Diet (e.g. ad libitum): free acces to A04 C pelleted diet.
- Water (e.g. ad libitum): was filtered by a FG Millipore membrane (0.22 micron) and provided ad libitum
- Acclimation period: 5 days before the study beginning
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 °C +/- 2°C
- Humidity (%): 30 to 70 %
- Air changes (per hr): 12 cycles/hour
- Photoperiod (hrs dark / hrs light): 12h/12h
IN-LIFE DATES: From: 2 july 1998 To: 16 july 1998
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Remarks:
- purified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: for males : 5 cm x 6 cm; for females : 5 cm x 7 cm
- % coverage: approximately 10% (calculated by Meeh's formula)
- Type of wrap if used: hydrophilic gauze pad pre-moistened with 2 ml of water. It's held in contact by an adhesive hypoallergenic aerated semi-occlusive dressing and a restaining bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): any residual test substance was removed using a dry gauze pad
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg of animal body weight - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg. To dose applied to each animal was ajusted according to body weight determined on the day of treatment.
- No. of animals per sex per dose:
- 5 females/dose
5 males / dose - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: rats were observed frequently during the hours following administration of the test substance, for detection of possible treatment-related clinical signs. thereafter, observation of the animals was made at least once a day.
animals were weight individually just before administration of the test substance on day 1 and then on day 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: After death, macroscopic examination of the main organs (digestive tract, heart, kidney...)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No deaths occured
- Clinical signs:
- other: No clinical signs
- Gross pathology:
- Necropsy after the death revealed no abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under experimental conditions, the dermal LD0 of didecanoyl peroxide is higher than 2000 mg/kg in rats.
- Executive summary:
The acute dermal toxicity of didecanoyl peroxide (purity: 99.1%) was evaluated in rats according to OECD N° 402 guideline and EC 92/69/EEC B.3 guidelines (Acute Toxic Standard Method). It was applied to the skin of groups of 5 males and 5 females Sprague Dawley rats at dose of 2000 mg/kg with a semi-occlusive dressing for 24 hours. Following treatment, rats were observed frequently following hours after treatment. Thereafter, they were observed daily. Rats were weighted the day of treatment (day 1), then days 8 and 15. A necropsy examination was performed at the time of scheduled euthanasia (Day 15).
No deaths occurred during the study. No clinical signs and no cutaneous reactions were observed. The body weight gain was lower for 1 female during the period of day 1 to day 8, and for another female during the period of day 8 to day 15. Necropsy after death reveals no abnormalities.
Under experimental conditions, the dermal LD0 of didecanoyl peroxide is equal to or higher than 2000 mg/kg in rats.
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