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EC number: 700-503-1 | CAS number: 101238-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012 - 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study conductd according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2,6,6-tetramethylpiperidin-4-yl dodecanoate
- EC Number:
- 700-503-1
- Cas Number:
- 101238-01-1
- Molecular formula:
- C21 H41 N O2
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-yl dodecanoate
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- The dry constituents were blended in the correct proportions with sphagnum peat 10%, kaolin clay 20%, industrial sand 70% and mixed thoroughly, either in a large-scale laboratory mixer or small electric cement mixer. Moisture content was then determined by drying a small sample at 105°C and re-weighing. Deionized water was added to give an overall moisture content of about 27% of the dry weight, and the medium was thoroughly mixed.
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- Species: Eisenia foetida
Batch No.: EEf20111014-1
Age: older than 2 months
Weight: 362 mg -405 mg
Amount: 80 individuals
Source: Zhuhai Hongming Earthworm Breeding Park
Selected reasons:
The recommended test species is Eisenia foetida (Michaelsen). Although this is not a typical soil species, it occurs in soil rich in organic matter. Its susceptibility to chemicals resembles that of true soil-inhabiting species, it has a short life cycle and is very prolific. It is available commercially and can be bred readily in a wide range of organic waste materials. Cocoons can be purchased commercially or distributed from a central source to ensure the same strain is used. “The Guidelines for the Testing of Chemicals” recommend the use of this species.
Holding:
All earthworms are to be obtained and held in the laboratory for 14 days under the same surroundings before used. During the holding period, all the earthworms should be healthy. They are breeding for 24h in the artificial soil before artificial soil test.
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 17.5 - 19.7 deg. C
- pH:
- 6.5 (start of the test)
- Moisture:
- 73.0 - 98.0%
- Details on test conditions:
- Type of test: Acute toxicity test in artificial soil test
Test organism: Eisenia foetida.
Test duration: 14d
Test concentration: One test group of 1000 mg/kg dry soil was designed
Control: A blank control was designed
Replicates: 4 replicates/blank control, 4 replicates/test substance
Test organism number: 10 earthworms/parallel
Preparation of test system: About 10g of a mixture of fine ground quartz sand and 550mg of test substance are mixed with 740g wet artificial soil for each test container to form 1000mg/kg dry soil test systems. Four test systems are prepared for each test group.
Temperature in incubator: 17.5°C-19.7°C
Light condition: Continuous light, the light intensity was 562 lx at the beginning of the test and 624 lx at the end of the test. - Nominal and measured concentrations:
- 1000 mg/kg dw
- Reference substance (positive control):
- yes
- Remarks:
- chloracetamide
Results and discussion
Effect concentrations
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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