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EC number: 257-821-4 | CAS number: 52298-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: company guideline similar to OECD 401
- Deviations:
- no
- Principles of method if other than guideline:
- Due to its slightly higher sensitivity, demonstrated in pre-tests, only male rats were tested in the main study.
- GLP compliance:
- no
- Remarks:
- prior to GLP implementation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-amino-2,5-dimethoxy-N-phenylbenzenesulphonamide
- EC Number:
- 257-821-4
- EC Name:
- 4-amino-2,5-dimethoxy-N-phenylbenzenesulphonamide
- Cas Number:
- 52298-44-9
- Molecular formula:
- C14H16N2O4S
- IUPAC Name:
- 4-amino-2,5-dimethoxy-N-phenylbenzene-1-sulfonamide
- Details on test material:
- - Name of test material (as cited in study report): Chinonbasesulfanilid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG breeding station
- Weight at study initiation: 80 - 114 grams (average 94 grams)
- Fasting period before study: 16 hours
- Housing: plastic-cages with wood shavings
- Diet : Altromin 1324 (Fa. Altrogge, Lage/Lippe) ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% - Doses:
- 530, 1000, 1600, 2500, 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 male
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations: daily; weighing: intially, after 7 days, after 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- Probit analysis (according to LINDER und WEBER)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 445 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 630 mg/kg bw 0 of 10
1000 mg/kg bw 1 of 10
1600 mg/kg bw 6 of 10
2500 mg/kg bw 10 of 10
5000 mg/kg bw 10 of 10 - Clinical signs:
- other: Lethaly intoxicated animlas showed disequilibrium and prone position before dying.
- Gross pathology:
- No abnormal findings in survivors or animals found dead.
- Other findings:
- No other findings.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50: 1445 mg/kg bw
- Executive summary:
Acute toxicity of Chinonbasesulfanilid was tested according to a company operating procedure similar to OECD 401. Following this protocol five doses of the test item were administered by gavage to 10 male rats per dose. During the observation period of 14 days mortality occured at doses of 1000 (1/10), 1600 (6/10), 2500 (10/10), and 5000 mg/kg bw (10/10). The LD50 of 1445 mg/kg was calculated by probit analysis (according to Linder and Weber).
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