Tricyclopentylphosphine

Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Remove patient to fresh air. Symptomatic treatment.

Emergency measure - Eyes: Immediately irrigate with plenty of water for 15 minutes.

Obtain immediate medical attention.

Emergency measure - Skin: Remove contaminated clothing without delay and lanuder

before re-use. Rinse thoroughly with soap and water.  Do not

omit cleaning hair or under fingernails if contaminated.

Emergency measure - Ingestion: Seek medical attention.

Fire-fighting measures

Recommended extinguishing agent: Dry chemical powder pressurised with nitrogen, or absorbent

clay may be used.  Reignition may occur.  If fire cannot be

controlled with extinguishing agent, keep a safe distance,

and allow the product to burn until consumed.

Product arising from burning: Products of combustion may contain oxides of phosphorus and

carbon.

Product determined by test: N

Protective equipment: NIOSH approved positive pressure, self-contained breathing

apparatus or air-line respirator with full face respirator

should be worn.

Accidental release measures

Emergency measures in case of spillage: Wear suitable protective clothing, see 2.3.1.

Block off source of spill, extinguish fire with appropriate

extinguishing agent. Remove sources of ignition.  Do not

contact spill with paper cloth or vermiculite as spontaneous

ignition will occur.  Cover spill with an inert absorbent

clay and place in a sealable container such that free air

volume is minimised.  Seal under inert gas.

Handling and storage

Handling: 1 The results of tests on 3 materials are reported in this

notification:-

a) Dowicil 200; The notified substance

b) Dowicil 75 containing 25% sodium bicarbonate

c) Dowicil 100 the Cis/Trans mixture

The majority of short term toxicity tests which are reported

in detail were conducted on Dowicil 75. Reference is made to

the results of suudies on Dowicil 200 some of which are of

poor quality. However, the results are considered acceptable

when they are supported by the results for Dowicil 75.

2 The following mutagenicity sudies were assessed for

notification purposes:-

For notification purposes a positive Ames and in vitro

cytogenetics test, in CHL cells, using Dowicil 200 were

assessed. Additional negative in vitro studies (cytogenetics

test in rat lymphocytes and UDS study in rat hepatocytes)

with Dowicil 200 are available but have not been assessed.

In addition studies using Dowicil 100, a positive in vitro

cell gene mutation test, without metabolic activation only,

in CHO cells and a negative in vivo mouse nicronucleus test,

are available but have not been assessed. Although a

negative in vivo study on the cis/trans isomer is available

the UK c.a. on the basis of the positive in vitro studies

with Dowicil 200, has requested a mouse micronucleus test

immediately post base-set. Therefore, the UK c.a. seeks the

opinion of other c.a.on the proposed mutagenicity testing

stratergy.

In addition, three reproductive developmental studies are

available on Dowicil 200. A decision on whether these

studies will be assessed for base-set will be made at the

risk assessment stage.

Storage: Store in sealed cylinders out of sun and away from heat, at

temperatures less than 50 deg C.  Areas containing this

material should have fire-safe practices and electrical

equipment in accordance with codes governing Class I

Flammable liquids.  Exposure to air and other oxidising

material must be avoided.  Store under an inert atmosphere

such as nitrogen.

Packaging of the substance and or preparation: Substance:

In steel or stainless steel cylinders.  Volume will vary

between 5 and 450 litres.

Preparation:

100 Imperial gallon steel cylinders built to DOT/TC 4BW-240

standards.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Transport: Containers should be transported upright and secured against
falling over. Containers should be sealed and suitably
labelled.


Substance:

ADR/RID Class: 4.2 Marginal #: 2431 Item #: 3

IMO Shipping name: Pyrophoric liquid, N.O.S.

Hazard Class: 4.2 UN Number: 2845

Transport label required: Spontaneously combustible

ICAO/ Shipping name: Pyrophoric liquid, N.O.S.

IATA Hazard Class: 4.2 UN Number: 2848

Transport label required: Spontaneously combustible


Technical name (N.O.S.): Tricyclopentylphosphine.

SpecialProvisions

Stability and reactivity

Danger other than fire: Strong reducing agent. Highly flammable.

Chemical reaction with water: None reported.

Dust explosion: Not applicable. Substance is a liquid.

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: In normal use, the substance is a catalyst and is recycled

in a continuous process.

Industry - Possibility of neutralisation: Oxidisation with dilute peroxide or hypochlorite will render

the substance harmless (A634).

Industry - Possibility of destruction: controlled discharge: Not recommended.

Industry - Possibility of destruction - incineration: Recommended method. Incineration in a facility equipped to

convert the substance to phosphoric acid is recommended

(A665).

Industry - Possibility of destruction - water purification: Not recommended.

Public at large - Possibility of recovery/recycling: Not applicable as the substance will not enter the public

domain.