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Diss Factsheets
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EC number: 636-196-5 | CAS number: 6902-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Publication
- Justification for type of information:
- Published research, where assessment of the substance was secondary to the primary research being conducted
Read across to other natural extract with some shared structural groups
Considered suitable for classification as Aquatic Acute 1, M=1
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 48 hours
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Reported 2023 as guideline study with supporting analysis
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Academic research work
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of all fresh test media and the control were analysed at exposure initiation (fresh) and during a renewal (spent).
The samples of test item concentrations of 45.5 mg/L, 4.3 mg/L plus the control at renewal (fresh) and at exposure termination (spent) were chemically analysed. - Vehicle:
- no
- Remarks:
- Water
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Young. 6 - 24 hours old
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 - 21.4 C
- pH:
- Approximately 7.2, adjusted in the media
- Dissolved oxygen:
- Approximately 8 mg/l
- Nominal and measured concentrations:
- 100, 45.5, 20.7, 9.4 and 4.3 mg/L nominal, plus the control.
In fresh samples at exposure initiation and at renewal, the determined concentrations of Genipin were in the range of 97.0 - 116.8% of the nominal concentration. The results confirm that the test item concentration was prepared correctly.
In spent samples at renewal and at exposure termination, the determined concentrations of Genipin were in the range of 79.2 – 90.0 of the nominal concentration. Therefore, the concentrations of Genipin were not fully stable during 24 h under test conditions.
The endpoint value was determined based on the nominal test item concentration as well as geometric means of determined concentrations of Genipin. - Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 20.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 21.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Controls valid
- Validity criteria fulfilled:
- yes
- Conclusions:
- Valid guideline study with analysis demonstrated moderate toxicity to Daphnia
Supporting analysis indicated slight, consistent, loss of test material across the replicates. The significance of this is not understood, but may hint at hydrolytic instability.
The substance is considered to be rapidly biodegradable.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Influence of Suspended Solids on the Combined Toxicity of Galaxolide and Lead to Daphnia magna
- Author:
- Fang C. et al
- Year:
- 2 015
- Bibliographic source:
Bull Environ Contam Toxicol (2015) 95:73–79
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- Research work following principles of OECD guideline
- GLP compliance:
- not specified
- Remarks:
- Academic research work
Test material
- Reference substance name:
- 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran
- EC Number:
- 214-946-9
- EC Name:
- 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran
- Cas Number:
- 1222-05-5
- Molecular formula:
- C18H26O
- IUPAC Name:
- 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Not specified
Test solutions
- Vehicle:
- no
- Remarks:
- Water
- Details on test solutions:
- Allowed to equilibrate in water for up to 24 hours (nominal 20 hours)
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Young. 6 - 24 hours old
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- pH:
- Approx 7, adjusted in the media
- Dissolved oxygen:
- Approx 7 mg/l
- Nominal and measured concentrations:
- 0.1, 0.2, 0.35, 0.60, 1.0, 2.0, 3.5 and 6.0 mg/l
Measured concentrations were 90 % to 102 % of nominal. Nominal used for reporting.
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.19 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Controls valid
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Considered very toxic to aquatic organisms
It is noted that some of the read-across parameters are not met, with Galaxolide having a lower water solubility and higher Log Kow, but the observed high toxicity to invertebrates is typical of the class of substance and typical of many plant extracts of this type.
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