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Diss Factsheets
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EC number: 636-196-5 | CAS number: 6902-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- 70 day feeding study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 70 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Peer reviewed research on the use of genipin in fish diet to enhance growth
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Dietary Geniposide on Growth, Flesh Quality, and Lipid Metabolism of Grass Carp, Ctenopharyngodon idella
- Author:
- Sun et al
- Year:
- 2 017
- Bibliographic source:
- Journal of the World Aquaculture Society, Vol 48 No 6
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Fish were fed with different levels of unrefined genipin mixed into diet to evaluate safety and to confirm if any improvement in growth rates
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Genipin
- EC Number:
- 636-196-5
- Cas Number:
- 6902-77-8
- Molecular formula:
- C11H14O5
- IUPAC Name:
- Genipin
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Material was the unrefined form of genipin, referred to as geniposide
When extracted, genipin is about 60% w/w 'actives'
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- Diet was analysed
- Details on sampling:
- Each batch of diet analysed
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Ctenopharyngodon idella
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 70 d
- Remarks on exposure duration:
- Period chosen to ensure growth and muscle development could be assessed
Test conditions
- Hardness:
- Not specified
- Test temperature:
- Maintained 25 - 30 C
- pH:
- MAintained pH 7 - 8
- Dissolved oxygen:
- Maintained at > 5 mg/l
- Nominal and measured concentrations:
- Feeding 100, 200, 400, 600 and 800 mg/kg bodyweight
Feed concentrations were based on measured body weights.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 70 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 480 other: mg/kg
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- act. ingr.
- Basis for effect:
- adult mortality
- Duration:
- 70 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 800 other: mg/kg bodyweight
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- adult mortality
- Details on results:
- At the higher levels of administration, fish fed with genipin had a reduced body-fat content and increased muscle groth
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Although a feeding study, it is noted that high dose levels by ingestion failed to cause toxici effects in adult fish
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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