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Diss Factsheets
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EC number: 907-481-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Twenty-five volunteers were expoded to 4% test substance in petrolatum. The test substance is applied under occlusive dressing to the same site on the volar forearm or back for five 48-hour periods. Prior to each exposure, the site was pre-treated with 2.5% aqueous SLS under occlusion for 24 hours. Following a 10-day rest period, a challenge patch of the test substance is applied to a different site for 48 hours under occlusion. The challenge site is pre-treated for 1 hour with 5% to 10% aqueous SLS under occlusion. Observations are made immediately after removal of the challenge patch and 24 hours thereafter.
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of 1,1-bis(phenethyloxy)ethane and [2-(1-ethoxyethoxy)ethyl]benzene
- EC Number:
- 907-481-4
- Molecular formula:
- C18H22O2 + C12H18O2
- IUPAC Name:
- Reaction mass of 1,1-bis(phenethyloxy)ethane and [2-(1-ethoxyethoxy)ethyl]benzene
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 25
- Sex: Male: 6; Female: 19
- Age: 18-32 (24 volunteers are between 18 and 23 years of age)
- Race: White - Clinical history:
- - healthy
- Route of administration:
- dermal
- Details on study design:
- - Concentration: 4% in petrolatum
- Pre-test: A patch of the test material was applied to normal sites on the volar forearms or backs for 48 hours under occlusion. No subject had any irritation from this material and it was decided to use SLS pre-treatment in the test.
- Maximization test: Performed according to Maximization Test (J.I.D.; vol. 47; No. 5; 363-409; 1966). The test substance is applied under occlusive dressing to the same site on the volar forearm or back of all subjects for five alternate-day 48-hour periods. Prior to each exposure, the site was pre-treated with 2.5% aqueous sodium lauryl sulfate under occlusive dressings for a 24-hour period. Following a 10-day rest period, a challenge patch of the test substance is applied to a different site for a 48-hour period under occlusion. The challenge site is pre-treated for 1 hour with 5% to 10% aqueous sodium lauryl sulfate under occlusion. Observations are made immediately after removal of the challenge patch and 24 hours thereafter.
Results and discussion
- Results of examinations:
- No effects were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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