Bis(4-(1,1,3,3-tetramethylbutyl)phenyl) ether

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 16 - October 02, 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Bis(4-(1,1,3,3-tetramethylbutyl)phenyl) ether

EC Number:

202-956-6

EC Name:

Bis(4-(1,1,3,3-tetramethylbutyl)phenyl) ether

Cas Number:

101-58-6

Molecular formula:

C28H42O

IUPAC Name:

1-(2,4,4-trimethylpentan-2-yl)-4-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]benzene

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

Light regime was set to a 12 -hour light / 12-hour dark cycle. A standard laboratory food KKZ-P/M(UEFT CEM SAS) was availiable ad libitum The animals recived tap wAter for human consumption. Supply of drinking water was unlimited.

Administration / exposure

Route of administration:

oral: gavage

Details on oral exposure:

undiluted test item

Doses:

2000 mg/kg bw.

No. of animals per sex per dose:

3 at the beginning and another 3 after 48 hours without mortality and nmo signs of intoxication .

Details on study design:

The animals were fasted over night prior to dosing, food but not water was with-held over-night. After the administration of the test item food was withheld for further 3 to 4 hours.

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The oral administration of Bis(4-(1,1,3,3-tertramethylbutyl)phenyl)ether to 6 female rats caused no clinical signs and no mortality. showed after oral administration of 2000 mg/kg bw.

Executive summary:

Undiluted Bis(4-(1,1,3,3-tertramethylbutyl)phenyl)ether was administered to 6 female rats. During 14 days after the administration the animals showd no signs of intoxication, no change of health nor any other adverse reaction.  The body weights of all animals increade in normal range during the study. All animals were necropsied. No visible pathological findings were observed in animals dosed with 2000 mg/kg body weight.