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EC number: 245-740-7 | CAS number: 23564-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 May 1990 - 23 August 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Thiophanate-methyl
- EC Number:
- 245-740-7
- EC Name:
- Thiophanate-methyl
- Cas Number:
- 23564-05-8
- Molecular formula:
- C12H14N4O4S2
- IUPAC Name:
- methyl N-{[2-({[(methoxycarbonyl)amino]methanethioyl}amino)phenyl]carbamothioyl}carbamate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Kbs:JW (Japanese-white)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kitayama LABES Co., Ltd. (Kyoto, Japan)
- Age at study initiation: 11 weeks old in male and female at the application
- Weight at study initiation: 2466.0±161.9 g in males and 2447.4±149.9 g in females at the application
- Housing: individually in stainless steel mesh cages (W 35xD 50xH 35cm)
- Diet: pelleted diet, RC-4 (0riental Yeast Co., Ltd., Tokyo), ad libitum
- Water: tap water, ad libitum
- Acclimation period: Quarantine: 13 days prior to the application.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.9± 0.6
- Humidity (%): 64.0± 1.7
- Air changes (per hr): 18
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The test item was spread on a piece of lint (12 x 14 cm) which was applied to the back of the animal.
- Type of wrap: elastic bandage (Elascot, TE-1902, Tokyo Eizai Lab. Co., Ltd.)
REMOVAL OF TEST SUBSTANCE
- Washing: the application site was washed with water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amounts applied: male: 27.1 - 31.0 mg/cm2, female: 28.0 - 30.4 mg/cm2
- For solids, paste formed: no - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations: 1 hour and at 3 hours after the application and thereafter at least once a day (except holidays); weighing: prior to the application and after 1, 2, 3, 7 and 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death was found in any rabbits.
- Clinical signs:
- other: 4 males and 3 females in the dosed groups showed reddening of the application area. This sign continued for 2 days after the application.
- Gross pathology:
- No abnormality was observed in any rabbits of either sex.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 was determined to be > 2000 mg/kg bw.
- Executive summary:
An acute dermal toxicity study was performed with the test item in Kbs:JW rabbits. Twenty animals were divided into 1 control and 1 dose group consisting of 5 rabbits in each sex. The test item was dermally applied to the animals of the dose group at 2000 mg/kg bw and the animals of the control group were treated the same manner as the animals of the dosed group except for the test substance application. 4 males and 3 females in the dose group showed reddening of the application area. This observation continued for 2 days after the application. Body weight was not affected by the treatment. No death was observed in any rabbits of either sex. No abnormality on necropsy was observed in any rabbits. The acute dermal LD50 was determined to be > 2000 mg/kg bw.
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