tert‐butyl N‐[(1R,2S,5S)‐2‐amino‐5‐(dimethylcarbamoyl)cyclohexyl]carbamate, oxalic acid (1:1)

Guidance on Safe Use

First-aid measures

General notes

Take off immediately all contaminated clothing.

In all cases of doubt, or when symptoms persist, seek medical advice.

Symptoms may develop several hours following exposure; medical observation therefore necessary

for at least 48 hours.

Following inhalation

Provide fresh air.

If breathing is irregular or stopped, immediately seek medical assistance and start first aid actions.

Following skin contact

After contact with skin, take off immediately all contaminated clothing, and wash immediately with

plenty of water and soap.

Following eye contact

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Remove contact lenses, if present and easy to do. Continue rinsing.

Following ingestion

Rinse mouth immediately and drink plenty of water.

Do NOT induce vomiting.

In case of unconsciousness place person in the recovery position. Never give anything by mouth.

Call a physician immediately.

Notes for the doctor

None.

Fire-fighting measures

Suitable extinguishing media

water, foam, alcohol resistant foam, fire extinguishing powder

Unsuitable extinguishing media

water jet

Special hazards arising from the substance or mixture

Hazardous decomposition products:

Reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are not known.

Danger of dust explosion.

Deposited combustible dust has considerable explosion potential.

Hazardous combustion products

nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)

Advice for firefighters

In case of fire and/or explosion do not breathe fumes.

Co-ordinate firefighting measures to the fire surroundings.

Do not allow firefighting water to enter drains or water courses.

Collect contaminated firefighting water separately.

Fight fire with normal precautions from a reasonable distance.

Special protective equipment for firefighters

chemical protection suit, self-contained breathing apparatus (SCBA)

Accidental release measures

Personal precautions, protective equipment and emergency procedures

For non-emergency personnel

Remove persons to safety.

Ventilate affected area.

Control of dust.

Eliminate all ignition sources if safe to do so.

Do not breathe dust.

Do not get in eyes, on skin, or on clothing.

Wearing of suitable protective equipment (including personal protective equipment referred to under

Section 8 of the safety data sheet) to prevent any contamination of skin, eyes and personal clothing.

For emergency responders

Wear breathing apparatus if exposed to vapours/dust/spray/gases.

Environmental precautions

Keep away from drains, surface and ground water.

Retain contaminated washing water and dispose of it.

If substance has entered a water course or sewer, inform the responsible authority.

Methods and material for containment and cleaning up

Advice on how to contain a spill

Take up mechanically.

Advice on how to clean up a spill

Take up mechanically.

Collect spillage.

Other information relating to spills and releases

Place in appropriate containers for disposal.

Ventilate affected area.

Handling and storage

Precautions for safe handling

Measures to prevent fire as well as aerosol and dust generation

Use local and general ventilation.

Keep away from sources of ignition - No smoking.

Take precautionary measures against static discharge.

Only vacuum cleaners containing no ignition sources may be used for combustible dusts.

Use explosion-proof electrical/ventilating/lighting/equipment.

Use only non-sparking tools.

Specific notes/details

Layers, deposits and heaps of combustible dust must be considered, like any other source which can

form a hazardous explosive atmosphere.

Dust deposits may accumulate on all deposition surfaces in a technical room.

Danger of dust explosion.

Measures to protect the environment

Avoid release to the environment.

Advice on general occupational hygiene

Do not eat, drink and smoke in work areas.

Remove contaminated clothing and protective equipment before entering eating areas.

Do not breathe dust.

Do not get in eyes, on skin, or on clothing.

Wash thoroughly after handling.

Preventive skin protection (barrier creams/ointments) is recommended.

Conditions for safe storage, including any incompatibilities

Explosive atmospheres

Removal of dust deposits.

Only vacuum cleaners containing no ignition sources may be used for combustible dusts.

Flammability hazards

Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

Take precautionary measures against static discharge.

Ground/bond container and receiving equipment.

Incompatible substances or mixtures

Incompatible materials: see section 10.

Protect against external exposure, such as

heat, light

Consideration of other advice

Keep away from food, drink and animal feedingstuffs.

Store in a well-ventilated place. Keep container tightly closed.

Ventilation requirements

Provision of sufficient ventilation.

Packaging compatibilities

Keep only in original container.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

Not subject to transport regulations

Exposure controls / personal protection

Exposure controls

Appropriate engineering controls

General ventilation.

Individual protection measures (personal protective equipment)

Eye/face protection

Wear eye/face protection.

Hand protection

Protective gloves

Material Material thickness Breakthrough times of the glove

material

NBR: acrylonitrile-butadiene rubber ≥ 0,11 mm >480 minutes (permeation: level 6)

Wear suitable gloves.

Chemical protection gloves are suitable, which are tested according to EN 374.

Check leak-tightness/impermeability prior to use.

In the case of wanting to use the gloves again, clean them before taking off and air them well.

For special purposes, it is recommended to check the resistance to chemicals of the protective gloves

mentioned above together with the supplier of these gloves.

Other protection measures

Protective clothing for use against solid particulates.

Respiratory protection

In case of inadequate ventilation wear respiratory protection.

Particulate filter device (EN 143).

Environmental exposure controls

Use appropriate container to avoid environmental contamination.

Keep away from drains, surface and ground water.

Stability and reactivity

Reactivity

This material is not reactive under normal ambient conditions.

Chemical stability

The material is stable under normal ambient and anticipated storage and handling conditions of tem-

perature and pressure.

Possibility of hazardous reactions

Danger of dust explosion.

Conditions to avoid

Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

Take precautionary measures against static discharge.

UV-radiation/sunlight.

Incompatible materials

oxidisers

Hazardous decomposition products

Reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill

and heating are not known.

Disposal considerations

Waste treatment methods

This material and its container must be disposed of as hazardous waste.

Sewage disposal-relevant information

Do not empty into drains.

Waste treatment of containers/packagings

Completely emptied packages can be recycled.

Handle contaminated packages in the same way as the substance itself.

Remarks

Please consider the relevant national or regional provisions.