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EC number: 500-046-6 | CAS number: 26183-52-8 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- Laboratory and outdoor stream mesocosm study
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please refer to the Category Approach Justification provided in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.16 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Source, WoE, 68131-39-5, Shell, 1995, WTC 58-95, P. promelas, 10 d, RL2
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.28 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Source, WoE, 68131-39-5, Shell, 1995, WTC 58-95, P. promelas, 10 d, RL2
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.11 - <= 0.28 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other:
- Remarks:
- Source, WoE, 68131-39-5, Shell, 1995, WTC 58-95, P. promelas, 10 d, RL2
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.33 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: swimming performance
- Remarks on result:
- other:
- Remarks:
- Source, WoE, 68131-39-5, Shell, 1995, WTC 58-95, L. macrochirus, 10 d, RL2
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.33 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: mortality and growth rate
- Remarks on result:
- other:
- Remarks:
- Source, WoE, 68131-39-5, Shell, 1995, WTC 58-95, L. macrochirus, 10 d, RL2
- Endpoint:
- fish, juvenile growth test
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The effect of the test substance on survival and growth of juvenile fish were investigated in the laboratory and in outdoor stream mesocosms. In the laboratory fish were exposed for 10 d and in the outdoor stream mesocosms for 30 d. 10 fish were exposed per test concentration in both experiment.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- TEST ORGANISM
- Common name: bluegill sunfish
- Source: laboratory bioassay: culture pond of the Biological Field Station, University of Mississippi, USA; outdoor stream mesocosm: local hatchery
- Weight at study initiation (mean and range, SD): laboratory bioassay: mean dry weight: 0.27 g, SD = 0.11, n = 10; outdoor stream mesocosm: mean weight: 1.19 g, SD = 0.32, n = 10.
FEEDING DURING TEST - no data - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 10 d
- Remarks on exposure duration:
- laboratory bioassay and 30 d outdoor stream mesocosm
- Hardness:
- Laboratory bioassay: 4 mg/L as CaCO3
Outdoor stream mesocosm: Experiment 1: range: 10 - 20 mg CaCO3/L, mean: 14.6 CaCO3/L; Experiment 2: range: 7 - 26 mg CaCO3/L, mean: 11.1 mg CaCO3/L - Test temperature:
- Laboratory bioassay: mean 13.3 °C (SD = 1.77, n = 22)
Outdoor stream mesocosm: Experiment 1: range: 15.6 - 22.5 °C, mean: 23.99 °C; Experiment 2: 22.5 - 27.8 °C, mean: 23.35 °C - pH:
- Laboratory bioassay: 6.71
Outdoor stream mesocosm: Experiment 1: range: 5.88 - 6.29, mean: 6.04; Experiment 2: range: 5.75 - 6.44, mean: 5.95 - Dissolved oxygen:
- Laboratory bioassay: 9.7 mg/L
- Nominal and measured concentrations:
- Laboratory bioassay:
nominal: 0, 50, 150, 500, 1000 and 2000 µg/L
measured: <10, 35, 160, 460, 960 and 2190 µg/L
Outdoor stream mesocosm:
Experiment 1: nominal: 0, 100, 200 and 400 µg/L; measured: 30, 30, 60 and 70 µg/L
Experiment 2: nominal: 0, 100, 300 and 600 µg/L; measured: 0, 40, 50 and 70 µg/L - Reference substance (positive control):
- no
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.16 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.33 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: swimming performance
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.33 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.33 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- - Fish weights (individual and mean values) on day 0, 14 (if measured) and 28: fish weights and length (mean values) see Table [1]
- Type of and number with behavioural abnormalities: following exposure to a surfactant concentration of 0.460 mg/L for 10 d in the laboratory, the swimming performance was influenced significantly (critical swimming speed significantly less than of control fish). - Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The effect of the test substance on survival and reproduction of juvenile fish were investigated in the laboratory and in outdoor stream mesocosms. In the laboratory fish were exposed for 10 d and in the outdoor stream mesocosms for 30 d. 10 fish were exposed per test concentration in both experiment.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnow
- Source: culture facilities at the University of Mississippi, USA
- Age at study initiation (mean and range, SD): stream outdoor mesocosm: approx. 4 month old
- Weight at study initiation (mean and range, SD): laboratory bioassay: mean wet weight: 0.57 g, SD = 0.27, n = 7
- Method of breeding: stream outdoor mesocosm: fish were introduced into four spawning chambers in each of the eight stream mesocosms 12 d prior to initiation of treatment in experiment 1 and 5 d prior to initiation of treatment in experiment 2. Spawning chambers, each consisting of an 8 L plastic container with a 0.6 cm mesh bottom, were suspended in the pool sections of the stream mesocosms. A halved section of 10 cm diameter PVC pipe was placed in each spawning chamber to serve as a spawning substrate. Spawning substrates were monitored daily. If spawning occurred, eggs were counted and then they were placed in an aerated incubation chamber suspended in the mixing chamber of the stream mesocosm. Eggs were monitored daily and diseased eggs were removed.
- Feeding during test
- Food type: frozen brine shrimp (Artemia salina) and conditioning food (TetraMin)
- Amount: no data
- Frequency: daily
ACCLIMATION
- Acclimation period: Experiment 1: 12 d, experiment 2: 5 d
- Acclimation conditions (same as test or not): yes
- Type and amount of food: see above
- Feeding frequency: see above - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 10 d
- Remarks on exposure duration:
- laboratory bioassay and 30 d outdoor stream mesocosm
- Hardness:
- Laboratory bioassay: 4 mg/L as CaCO3
Outdoor stream mesocosm: Experiment 1: range: 10 - 20 mg CaCO3/L, mean: 14.6 CaCO3/L; Experiment 2: range: 7 - 26 mg CaCO3/L, mean: 11.1 mg CaCO3/L - Test temperature:
- Laboratory bioassay: mean 13.3 °C (SD = 1.77, n = 22)
Outdoor stream mesocosm: Experiment 1: range: 15.6 - 22.5 °C, mean: 23.99 °C; Experiment 2: 22.5 - 27.8 °C, mean: 23.35 °C - pH:
- Laboratory bioassay: 6.71
Outdoor stream mesocosm: Experiment 1: range: 5.88 - 6.29, mean: 6.04; Experiment 2: range: 5.75 - 6.44, mean: 5.95 - Dissolved oxygen:
- Laboratory bioassay: 9.7 mg/L
- Nominal and measured concentrations:
- Laboratory bioassay:
nominal: 0, 50, 150, 500, 1000 and 2000 µg/L
measured: <10, 35, 160, 460, 960 and 2190 µg/L
Outdoor stream mesocosm:
Experiment 1: nominal: 0, 100, 200 and 400 µg/L; measured: 30, 30, 60 and 70 µg/L
Experiment 2: nominal: 0, 100, 300 and 600 µg/L; measured: 0, 40, 50 and 70 µg/L - Reference substance (positive control):
- no
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.16 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.28 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.11 - 0.28 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- - Observed effects at each concentration for each observation time: see Table [1]
- Mortality in the controls: no mortality
- Behavioural observation of the fish: no data
Referenceopen allclose all
Table 1: Mean lengths and weights of juvenile bluegills after 30 d exposure in stream mesocosms
Test parameter |
Surfactant concentration [mg/L] |
|||
0 |
0.080 |
0.160 |
0.330 |
|
Total length (cm) |
6.64 (0.39) |
6.64 (0.37) |
6.52 (0.44) |
6.53 (0.51) |
Wet weight (g) |
4.87 (0.85) |
4.66 (0.99) |
4.59 (1.05) |
4.77 (1.10) |
Dry weight (g) |
1.18 (0.12) |
1.12 (0.21) |
1.12 (0.25) |
1.18 (0.28) |
Values in parentheses: SD
Table 1: Mortality and reproduction of fathead minnows in 30 d mesocosms
Test parameter |
Measured concentration of surfactant [mg/L] |
|||||
0 |
0.080 |
0.160 |
0.280 |
0.330 |
0.550 |
|
Experiment 1 |
||||||
No. of dead adults |
0/24 |
0/24 |
0/24 |
- |
6/24 |
- |
No. of clutches |
2 |
4 |
1 |
- |
1 |
- |
No. of eggs laid |
340 |
- |
209 |
8 |
- |
1 |
Day of last clutch |
8 |
6 |
3 |
- |
2 |
- |
Experiment 2 |
||||||
No. of dead adults |
0/24 |
0/24 |
- |
0/24 |
- |
0/24 |
No. of clutches |
7 |
3 |
- |
3 |
- |
0 |
No. of eggs laid |
742 |
- |
447 |
- |
240 |
0 |
Day of last clutch |
20 |
10 |
- |
7 |
- |
0 |
No. of surv. larvae |
123 |
76 |
- |
51 |
- |
0 |
Description of key information
EC20 (30d) >= 2.92 - <= 5.14 mg/L Pimephales promelas (QSAR estimation)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.92 mg/L
Additional information
As no study is available for decan-1-ol, ethoxylated, 1-2.5EO (CAS 26183 -52 -8), a category read-across is prepared to a chronic fish study conducted with an similar alcohol ethoxylate (C14-15, 7 EO). In that study conducted with two different fish species (bluegill sunfish and fathead minnow) the effects of alcohol ethoxylate (C14-15, 7 EO) were determined (Shell, 1995). In two experiments fish were exposed for 10 d in a laboratory assay and for 30 d in an outdoor stream mesocosm. Effect parameters determined were survival and growth of juvenile bluegills and survival and reproduction of fathead minnows. In the laboratory experiment the NOEC for survival and swimming performance of bluegills and for survival of fathead minnows was 0.16 mg/L. In the stream mesocosm the NOEC for bluegill survival and growth was >0.33 mg/L and for fathead minnow survival 0.28 mg/L. There was an indication of decreased egg laying by fathead minnow in the streams at concentrations of 0.33 mg/L or greater.
Nevertheless, the data allow not to derive a precise long-term effect value for the described mixture decan-1 -ol, ethoxylated, 1-2.5EO (CAS26183 -52 -8). Alcohol ethoxylate specific QSARs were developed to describe the toxicity of varying mixtures (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006). The QSARs considered all three trophic levels (algae, invertebrates and fish). The effects are described as EC20 values, since the QSARs are more robust for the EC20 values than for NOEC or EC10 values (Boeije et al., 2006). For the described mixture decan-1-ol, ethoxylated, 1-2.5EO (CAS 26183 -52 -8) the QSAR for long-term toxicity on fish (Pimephales promelas) (Boeije et al., 2006) results in an EC20 (30d) value between 2.92 and 5.14 mg/L. This result is used as key information for the further assessment.
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