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EC number: 268-706-3 | CAS number: 68133-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 29, 2015 - January 5, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The analog substance has a very similar chemical structure to the substance being registered. The reported substance has a C8 carbon chain with two methyl groups and two double bonds, and the analog substance has a C9 carbon chain with two methyl groups and two double bonds in the same positions.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Both the source and target substances were tested in very pure forms. The target substance was tested at 100% purity, and the source substance was tested at 99% purity with 1% tocopherol added as a preservative.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- Test results from one test substance flask were improperly recorded. The results reported are based on the results for the other two flasks.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(3,7-dimethyl-2,6-nonadien-1-yl)-cyclopentane
- Cas Number:
- 1206769-45-0
- Molecular formula:
- C16H26O
- IUPAC Name:
- 2-(3,7-dimethyl-2,6-nonadien-1-yl)-cyclopentane
- Reference substance name:
- 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
- EC Number:
- 233-466-0
- EC Name:
- 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
- Cas Number:
- 10191-41-0
- Molecular formula:
- C29H50O2
- IUPAC Name:
- 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol
- Test material form:
- liquid
Constituent 1
additive 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Easton Wastewater Treatment Facility
- Storage conditions: aerated at test temperature until use
- Storage length: plates incubated for 48 hrs
- Initial cell/biomass concentration: 1,000 mg total suspended solids/L
- Water filtered: yes
- Type and size of filter used, if any: 2 mm - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 10 other: mg C/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: modified biochemical oxygen demand test dilution water prepared with high quality water
- Test temperature: 20 +/- 3 degrees C
- pH: 7.6
- pH adjusted: yes
- Aeration of dilution water: yes
- Suspended solids concentration: =< 30 mg/L
TEST SYSTEM
- Culturing apparatus: 4 L amber bottles
- Number of culture flasks/concentration: 3
- Method used to create aerobic conditions: Air entering chambers was passed over Drierite and then Ascariate. Aeration was done for a 24-hr period , and then the flow of air was stopped.
- Details of trap for CO2 and volatile organics if used: Air exiting the test bottles was passed through three gas washing bottles. Each of the gas washing bottles contained 100 mL of 0.5 M KOH.
SAMPLING
- Sampling frequency: days 3, 6, 8, 13, 17, 20, 23, and 27
- Sampling method: The CO2 trap nearest the test chamber was removed. The two other traps were moved down one position, and then a new trap added.
- Sample storage before analysis: Samples from the end of the study were aerated overnight, and then a sample removed for dissolved organic carbon analysis.
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: yes
- Toxicity control: yes
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- The value of CO2 evolved in the blank control chambers did not exceed 40 mg/L. The reference substance produced an average of 90.9% of theoretical CO2 evolved. Thus, the study is valid. The toxicity control degraded > 25% by day 14, and thus the substance is non-inhibitory at the test concentration.
% Degradation
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 73
- Sampling time:
- 27 d
- Details on results:
- The average percent biodegradation was greater than 60% by day 6. Thus fulfilling the 10 day window requiremetn.
BOD5 / COD results
- Results with reference substance:
- The reference substance produced an average of 90.9% of theoretical CO2 evolved.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The substance methyl apritone is readily biodegradable.
- Executive summary:
The ready biodegradability of the test substance methyl apritone was determined in an OECD 301B test. Inoculum was exposed to the test substance for 29 days, during which the amount of carbon dioxide evolved was measured. Sodium benzoate was used as a reference substance with toxicity controls, and inoculum blanks tested as well. Results of the controls and blanks were valid. The substance was degraded an average of 73%, and met the 10 -day window requirement. The substance is therefore readily biodegradable.
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