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EC number: 617-694-1 | CAS number: 85261-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]nonanamide
- EC Number:
- 617-694-1
- Cas Number:
- 85261-19-4
- Molecular formula:
- C16H33NO6
- IUPAC Name:
- N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]nonanamide
- Test material form:
- solid
- Details on test material:
- sample no. SCF-KEE-00462
active content (100% minus by-products): 90,0 % (w/w)
Propylene glycol: 0,8 % (w/w)
(by GC)
NMG: 0,9 % (w/w)
(by GC)
Polyol/sorbitol: 0,7 % (w/w)
(by HPLC)
NAME: 0,1 % (w/w)
(by GC)
Aliphatic acid: 3,6 % (w/w)
(by GC)
Water: 0,1 % (w/w)
(by Karl-Fischer titration)
Methanol: <0,1 % (w/w)
(by GC)
Other by-products: 3,8 % (w/w)
(by GC)
Appearance at 20°C: beige wax (by visual examination)
Batch No.: SCF-KEE-00462
Analytical Report No.: 17-009338-1
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Good quality tap water which had been dechlorinated for at least 24 hours was used. The total
hardness of the test water was 121.6 mg (CaC03)/L and pH was 8.08 at room temperature.
Characteristics of the dilution water are measured at least twice a year by Jiangsu Provincial
Center for Disease Prevention and Control.
Test organisms
- Test organisms (species):
- other: Gobiocypris rarus
- Details on test organisms:
- The Rare minnow, Gobiocypris rarus, was used in the test on the basis of such important
practical criteria as, for example, their ready availability throughout the year, ease of maintenance,
convenience for testing and any relevant economic, biological or ecological factors. The test
species of Rare minnow, Gobiocypris rarus (Batch No.: F20180315G), were bred by our own lab.
A population of a single stock was used in the test.
(1) Holding of fish
Fish to be used in the test were held for at least 7 days in water of the quality and temperature tobe used in the test.
A photoperiod of 12 hours light, provided by overhead fluorescent tubes, and 12 hours dark was
maintained. The oxygen concentration was varied from 86 % to 93 % of the air saturation. And
the temperature was controlled between 22.9°C and 23.3°C, pH: 7.63 ~7.79.
The fish was fed daily during the holding period on proprietary fish food. They were held without
food for approximately 24 hours before being placed into the test vessels.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 130 - 137 mg/L CaCO3
- Test temperature:
- 23 - 23.1 °C
- pH:
- 7.68 - 7.84
- Dissolved oxygen:
- 90 - 96 %
- Nominal and measured concentrations:
- 100 mg/L and control
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- LC50 24h = 293 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results showed that under valid semi-static conditions (24 h renewal), the 96 h-LC50 of test
substance to fish (Rare minnow, Gobiocypris rarus) was greater than the nominal concentration
of 100 mg/L (mean measured concentration 95.7 mg/L), while the maximum concentration
causing no mortality (96 h-LC0) was equal to the nominal concentration of 100 mg/L (mean
measured concentration 95.7 mg/L). i.e.:
96 h-LC5o > 100 mg/L (mean measured concentration 95.7 mg/L);
96 h-LCo = 100 mg/L (mean measured concentration 95.7 mg/L). - Executive summary:
Undersemi-static conditions(24h renewal),the acutetoxicityofthetestsubstanceofGlucamide
9(GA9)toRareminnow(Gobiocyprisrarus)was conducted accordingto:"The guidelines for
thetesting of chemicals" (HJ/T153-2004),"The Guidelines forthe TestingofChemicals, Effects
onBiotocSystems" (the 2ndedition) (2013); and with referenceto Procedure 203 of the
"Guidelines forTestingof Chemicals" of theOECD: "Fish, AcuteToxicityTest" (1992).
Arange-finding testandthenalimit testwereperformedrespectively.Nominalconcentrations of
1.0,10.0and100 mg/L wereusedin the range-findingtest,while thenominalconcentration of
100 mg/L wasused in thelimittest. The mean of the measured concentrations was 95.7 mg/L,
ranging from 92.5mg/Lto 98.6mg/L duringthe test period (0, 24,48,72, 96h).The analytical
results showed thatthe measuredconcentration of the test substancewasconsistent inthe test
medium throughout the 96-hour test period (deviation within20%). Thus asemi-staticprocedure
(24 h renewal) was reasonable.
Five fish per treatment with no replication were tested in the range-finding test while three
replicates ofsevenfisheachwere tested in the control and limitconcentration ofthe limit test.
The test fishes were exposed for 96 hours to the testsolution.
During the test period, the pH values of the control mediums and test mediums were between
7.66 and 7.84 the Dissolved Oxygen (DO) values variedfrom 90 % to 96 % of the airsaturation
at the test temperature; thetotalhardnesswas in the range of 130 mg (CaC03)/Lto137 mg
(CaC03)/L; the temperature of the test mediums was maintainedin the range of23.0 °Cto23.2°C
and allfishes inthe controlgroupwere normal. With thesameconditions, K2Cr207was used as
the positive controlsubstance, and the resulting24h-LC50was293mg/L. So the study met the
acceptability criteria prescribed by the protocol and Test Guidelines (The mortality ofcontrol~
10%; pH: 6.0~8.5; dissolvedoxygenconcentration:>60% of the airsaturationvalue;
temperature: (23±2) °C;24h-LC50of K2Cr207in the range of200mg/L to 400 mg/L). Thus the
test wasconsideredvalid.
During the test period, all fish in the controlgroupsand treatedgroupswere alive and appeared
normal. The resultsshowedthat under validstatictest conditions, the 96 h-LC50of testsubstance
to fish (Rare minnow,Gobiocypris rarus)wasgreaterthan the nominalconcentration of100
mg/L (mean measuredconcentration95.7 mg/L), while the maximum concentration causing no
mortality (96 h-LC0)wasequalto the nominalconcentrationof l 00 mg/L (mean measured
concentration 95.7 mg/L). i.e.:
96 h-LC50>100 mg/L (mean measured concentration 95.7 mg/L);
96 h-LC0=100 mg/L (mean measured concentration 95.7 mg/L).
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