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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb 22 1995 - May 6 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
column elution method
Water solubility:
2.5 mg/L
Temp.:
20 °C
Remarks on result:
other: unbuffered solution
Water solubility:
2.3 mg/L
Temp.:
20 °C
pH:
>= 4 - <= 9

Preliminary test


In a preliminary test the water solubility was determined to be approx. 4 mg/L (Bayer AG, Nov. 11, 1993).


 


Summary of results


 




















































































 



acidic



                             neutral



pH 5.5 - 7



alkaline



 



phosphate buffer


c(NaH2P04 x 2H2O)


= 0.01 Mole/L


adjusted to pH 4


with cone. H3PO4



phosphate buffer


c(Na2HPO4 x 12H2O)


= 0.01 Mole/L


adjusted to pH 7


with cone. H3PO4



unbuffered water


in equilibrium


with


atmospheric


carbon dioxide



boratebuffer


c(Na2B4O7 x 10H2O)


= 0.01 Mole/L



pH



4



7



5



9



 



concentration



concentration



concentration



concentration



 



[mg/ L ]



[mg/ L ]



[mg/ L ]



[mg/ L ]



eluation column


flow rate (mL/min)



0.6



1.1



0.6



1.0



0.8



1.0



0.8



1.6



 



2.28



2.44



2.30



2.36



2.57



2.52



2.29



2.33



 



 



 



 



 



mean



2.36



2.33



2.54



2.31



rel. standard deviation



4.79 %



1.82%



1.39%



1 .22 %



 


The means from the results of 2 concentration measurements performed for each pH range are summarized in the table given above. It becomes evident that there is no significant dependence on the flow-rate showing that the solubility equilibrium was reached in all cases. By comparing the results from different series and considering the scope of the analytical error it becomes evident that there is no influence of the pH on the solubility between pH 4 and 9. However, there seems to be a slight influence of the salinity of solutions giving rise to higher concentrations measured for pure water.


 


The water solubility of the test substance is 2.5 mg/L in unbufferd aqueious solutions and 2.3 mg/L in buffered aqueous solutions in the range between pH 4 and pH 9 at 20 °C. The solubility is not influenced by the pH in the range between pH 4 and pH 9. The lower results for buffered solutions shows an influence of salinity on the solubility.

Description of key information

Water solubility: 2.5 mg/L at 20 °C [pure water]; 2.3 mg/L at 20 °C [buffer solution, pH 4-9] (OECD Guideline 105, column elution method)

Key value for chemical safety assessment

Water solubility:
2.5 mg/L
at the temperature of:
20 °C

Additional information

Solubility in pure water is selected as key value for CSA. The solubility is not influenced by the pH in the range between pH 4 and pH 9. The lower results for buffered solutions shows an influence of salinity on the solubility.