Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 476-720-8 | CAS number: 768-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Emergency measure - Inhalation: Remove to fresh air. If any trouble breathing, get immediate
medical attention. Administer artificial
respiration if breathing has ceased. If irritation or
symptoms occur or persist, consult a physician.
Emergency measure - Eyes: In case of eye contact, immediately rinse eyes thoroughly
with plenty of water. If wearing contact lenses, remove only
after initial rinse, and continue rinsing eyes for at least
15 minutes. If irritation occurs or persists, consult a
physician.
Emergency measure - Skin: In case of skin contact, while wearing protective gloves,
carefully remove any contaminated clothing, including shoes,
and wash skin thoroughly with soap and water. If irritation
or symptoms occur or persist, consult a physician.
Emergency measure - Ingestion: Rinse mouth and drink a glass of water. Do not induce
vomiting unless under the direction of a qualified medical
professional or Poison Control Center.
If symptoms persist, consult a physician immediately.
Fire-fighting measures
Recommended extinguishing agent: Water, carbon dioxide, and chemical powder.
Product arising from burning: Carbon oxides (COx). Hydrogen fluoride (HF). Boron oxides.
Product determined by test: N
Protective equipment: Full protective equipment must be worn including self-
contained breathing apparatus.
Accidental release measures
Emergency measures in case of spillage: Evacuate personnel from immediate vicinity.
Wear appropriate personal protective equipment conforming to
the relevant national or international standards.
Contain spillages with a suitable inert material (e.g. sand
or soil). Carefully transfer the spillage to waste
containers. Containers must be labelled in the same way as
original containers.
Clean the spillage area with water and detergent.
Dispose of waste material by incineration in accordance with
local regulations.
Handling and storage
Handling: This material will be handled within Schering-Plough by
qualified personnel and under controlled conditions. This
material will not be available to the general public. As
part of the Schering-Plough Industrial Hygiene Risk
Management program, workplace risk assessments are conducted
to identify the appropriate control strategies, including
engineering controls, personal protective equipment and work
practices, to provide adequate protection of the production
and laboratory personnel who handle this material.
Sampling and splitting the material in the Warehouse is
performed within laminar airflow booths with appropriate
Personal Protective Equipment (PPE). On the plant, Powder
Transfer System (PTS, vacuum operated), supplemented by
local exhaust ventilation (LEV) and PPE are used for all
manual handling operations. Finally, reaction mixture
solution sampling via Top Reactor Sampler (Rapid Transfer
Port). Contained sampling unit, minimal exposure to
reaction mixture
Keep container adequately sealed during material transport
or when material is not in use.
Wear appropriate personal protective equipment.
Storage: Keep in a cool, dry, well ventilated area.
Packaging of the substance and or preparation: Double polyethylene lined bags within fibre-board drums.
Typical weight of 25 kg per drum.
Transport information
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Marine transport (UN RTDG/IMDG)
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Air transport (UN RTDG/ICAO/IATA)
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Special provisions / remarks
- Remarks:
- Transport: Not applicable
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Exposure controls / personal protection
Stability and reactivity
Danger other than fire: Excessive heat. Oxidizers. Strong acids
Chemical reaction with water: Unknown.
Dust explosion: The substance is an organic powder presenting the
possibility of a dust explosion.
Dust explosion determined by test: N
Disposal considerations
Industry - Possibility of recovery/recycling: The substance is used as an intermediate in the synthesis of
an active pharmaceutical ingredient. Therefore it is
expected that it will be consumed in the processes where it
is employed. Hence the need for recovery/recycling of the
substance does not apply in this case.
Industry - Possibility of neutralisation: None known.
Industry - Possibility of destruction: controlled discharge: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Industry - Possibility of destruction - incineration: Any waste substance should be incinerated in a regulated
incinerator.
Industry - Possibility of destruction - water purification: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Industry - Possibility of destruction - other: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Public at large - Possibility of recovery/recycling: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Public at large - Possibility of neutralisation: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Public at large - Possibility of destruction: controlled discharge: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Public at large - Possibility of destruction - incineration: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Public at large - Possibility of destruction - water purification: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Public at large - Possibility of destruction - others: Not applicable as substance is a pharmaceutical intermediate
and is completely consumed during processing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.