Registration Dossier
Registration Dossier
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EC number: 472-110-0 | CAS number: 71868-15-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- Annex V C.1
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 250 mg CaCO3/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.93 mg/L
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 mg/L
- Basis for effect:
- mortality (fish)
- Details on results:
- % Concentration loss over test: 24 ... 71
- Conclusions:
- Under the study conditions, the 96 h LC50 was determined to be 2.93 mg/L.
- Executive summary:
A study was conducted to determine the acute toxicity of the test substance to zebra fish (Danio rerio) according to Directive/ECC (67/548/EEC), comparable to OECD Guideline 203, in compliance with GLP. Fish were exposed to the test substance for 96 h under semi-static conditions. Mortality was recorded. Test concentrations were verified analytically. Under the study conditions, the 96 h LC50 and NOEC values were determined to be 2.93 and 1 mg/L (geom. mean), respectively (ChemService, 2007).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.93 mg/L
Additional information
A study was conducted to determine the acute toxicity of the test substance to zebra fish (Danio rerio) according to Directive/ECC (67/548/EEC), comparable to OECD Guideline 203, in compliance with GLP. Fish were exposed to the test substance for 96 h under semi-static conditions. Mortality was recorded. Test concentrations were verified analytically. Under the study conditions, the 96 h LC50 and NOEC values were determined to be 2.93 and 1 mg/L (geom. mean), respectively (ChemService, 2007).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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