Registration Dossier
Registration Dossier
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EC number: 225-713-6 | CAS number: 5025-82-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- GLP compliance:
- yes
- Type of study:
- other: The LuSens test
- Justification for non-LLNA method:
- The LuSens test is an ARE Reporter Gene Assay that was developed by the BASF SE (Ludwigshafen, Germany) and is based on the OECD 442D Guideline (KeratinoSens As-say). The assay differs in some points from the OECD guideline.
Test material
- Reference substance name:
- 3-acetylthiazolidine-4-carboxylic acid
- EC Number:
- 225-713-6
- EC Name:
- 3-acetylthiazolidine-4-carboxylic acid
- Cas Number:
- 5025-82-1
- Molecular formula:
- C6H9NO3S
- IUPAC Name:
- 3-acetylthiazolidine-4-carboxylic acid
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Run / experiment:
- other:
- Parameter:
- other: Luciferase induction
- Value:
- 0
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Under the experimental conditions of this study, the test item, 3-acetylthiazolidine-4-carboxylic acid, was negative in the LuSens assay and is therefore considered not having the potential to activate the Nrf2 transcription factor.
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