Benzene, 1,1'-oxybis[methyl-, sulfonated, ammonium salts

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Remarks:

The study method is not reported in detail, the documentation of the study is not sufficient for assessment and is not convincing for an expert judgment. Therefore, the suitability of the test system cannont be confirmed and methodology applied cannot be verified.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test item was applied to skin without hair on the back of male white rats. Porous gauze dressings impregnated with the undiluted test substance (up to 4000 mg/kg bw) were held in contact with the skin for 4 hours.
After exposure the treated skin was not washed.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzene, 1,1'-oxybis[methyl-, sulfonated, ammonium salts

EC Number:

278-188-0

EC Name:

Benzene, 1,1'-oxybis[methyl-, sulfonated, ammonium salts

Cas Number:

75314-26-0

Molecular formula:

C14H13O4S . NH4 - C70H60O19S6 . 2NH4

IUPAC Name:

Benzene, 1,1'-oxybis[methyl-, sulfonated, ammonium salts

Constituent 2

Reference substance name:

Urea

EC Number:

200-315-5

EC Name:

Urea

Cas Number:

57-13-6

Molecular formula:

CH4N2O

IUPAC Name:

urea

Constituent 3

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

Test material form:

liquid

Details on test material:

Description : brown viscous liquid
Storage conditions: room temperature in the dark

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

The test item was applied to skin without hair on the back of male white rats. Porous gauze dressings impregnated with the undiluted test substance (up to 4000 mg/kg bw) were held in contact with the skin for 4 hours.
After exposure the treated skin was not washed.

Duration of exposure:

4 hours

Doses:

up to 4000mg/kg

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 4 000 mg/kg bw

Based on:

test mat.

Remarks on result:

no indication of skin irritation up to the relevant limit dose level

Mortality:

No

Clinical signs:

Not reported

Body weight:

Not reported

Gross pathology:

Not performed

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

The test item is not toxic via dermal administration up to 4000 mg/kg bw