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Diss Factsheets
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EC number: 947-919-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
One experimental study is available, in which the ready biodegradability of the target substance Fatty acids, C18-unsaturated, 2-hexyldecyl ester was investigated according to OECD guideline. However, since the key study conducted with the target substance was not GLP compliant, an additional read-across to a study conducted with the structurally and chemically closely related source substance Fatty acids, C16 - 18, 2-hexyldecyl esters (CAS 101227-09-2) was performed in order to support the key findings and to fulfill the standard information requirements laid down in Annex VII of the REACh Regulation (EC) No. 1907/2006. The source substance is characterized by similar fatty acid and alcohol components and is therefore considered a suitable representative for the assessment of the ready biodegradability of the target substance. Read-across was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 and a detailed justification of the analogue approach is provided in IUCLID section 13.
The target substance Fatty acids, C18-unsaturated, 2-hexyldecyl esteris characterized by high molecular weight (> 500 g/mole), very low water solubility (< 0.56 µg/L), a low estimated vapour pressure (< 0.0001 Pa at 20 °C, QSAR, ARChem SPARC v4.6), and a high estimated log Kow (QSAR, Vega v1.1.3). Experimental results from a standard biodegradation study showed that the target substance is readily biodegradable (94.6% within 28 d, OECD 301 B, CO2 evolution), which is confirmed by the read-across study with the source substance Fatty acids, C16 - 18, 2-hexyldecyl esters, CAS 101227-09-2 (90% degradation in 28 d, OECD 301 D). Thus, abiotic degradation via hydrolysis as well as evaporation and indirect photodegradation in air are not relevant environmental pathways.
According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA, 2017). Due to ready biodegradability and high potential for adsorption, the substance can be effectively removed in conventional STPs by biodegradation and sorption to biomass. Furthermore, the Guidance also states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will come into contact with activated sludge microorganisms. Therefore, only negligible amounts of the substance are expected to be released into the environment through conventional STPs, if at all. Whatever fraction is released into the aquatic environment will undergo extensive biodegradation and will preferentially distribute into the sediment compartment through sorption to organic matter, leading to a rapid reduction of the bioavailability of the substance in water. Thus, the relevant route of uptake in aquatic organisms is expected to predominantly occur by ingestion of particle bound substance, but the bioavailability of the substance is presumably very low based on its physico-chemical properties.
Overall, the available information on the environmental behavior, in combination with data from a similar substance, provide sufficient information to cover the data requirements set out in Regulation (EC) No. 1907/2006, Annex VII.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.