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EC number: 620-318-9 | CAS number: 1003049-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-09-12 to 2012-01-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- barium(2+) strontium(2+) λ¹-europium(1+) silicate
- EC Number:
- 620-318-9
- Cas Number:
- 1003049-92-0
- Molecular formula:
- Ba2-x-ySrxEuySiO4 (0.15
- IUPAC Name:
- barium(2+) strontium(2+) λ¹-europium(1+) silicate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Kißlegg
- Age at study initiation: 7 weeks (males), 9 weeks (females)
- Weight at study initiation: 169 g (from 151 to 198g)
- Fasting period before study: 17 hours
- Housing: air conditioned rooms, lighting 12 hours light 12 hours dark regime, single cages makrolon iii, conventional softwood granulate as bedding
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-23°C
- Humidity (%): 51-82%
- Photoperiod (hrs dark / hrs light):12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous Methocel K4M Premium
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30g/L for 300mg/kg dose, 200g/L for 2000 mg/kg
- Amount of vehicle (if gavage): 10mL/kg
- Lot/batch no. (if required):DT170406, 31/11, 32/11,35/11 - Doses:
- 300, 2000 mg/kg body weight
- No. of animals per sex per dose:
- 300 mg/kg bw : 3 males
2000 mg/kg bw: 3 males, 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were weighed before treatment and on days 2, 4, 6, 8, 11, 13, and 15 of the experimental part
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the study
- Clinical signs:
- other: No clinical signs were observed for dose group with 300mg/kg bw At dose group with 2000mg/kg bw one animal showed sunken flank on day 2 and 3 of experiment. It was caused by a clamped leg in the wire grid hindering the animal to have access to water and f
- Gross pathology:
- In one male animal of the high dose group red discolorations in the right lung were detected. These are acute multifocal hemorrhages initiated during the sacrifice.
- Other findings:
- none
Any other information on results incl. tables
Study Design
The test material was tested for acute toxicity in rats after single
oral administration of 300 and 2000 mg/kg body weight, respectively. The
test material was suspended in aqueous Methocel® K4M Premium solution.
For regulatory requirements, prior to testing, an in vitro skin
irritation study was performed to assess the irritant potential by means
of the Human Skin Model Test. No corrosive potential could be detected.
This study was performed according to GLP and the methods applied are
fully compliant with OECD TG 423.
Results
No deaths occurred during the study.
The study was started with 300 mg/kg in 3 male rats and no signs of
toxicity were seen. Subsequently, 3 male and 3 female rats were treated
with 2000 mg/kg. One male rat treated with 2000 mg/kg showed sunken
flank on day 2 and 3 of the experimental part. In all other rats treated
with 2000 mg/kg no signs of toxicity were seen.
One male rat treated with 2000 mg/kg showed a decrease of body weight on
day 2 of the experimental part. The clinical symptoms and decrease of
body weight in this one male animal was considered to be not treatment
related: the rat stuck with the right hind leg in the wire grid
overnight from day 1 to 2. Therefore, the animal had no access to food
or water during this time period. The body weight development of all
other rats was inconspicuous throughout the study.
At gross pathological examination focal, red discoloration in the right
lung was observed in one male rat which proved to be acute multifocal
hemorrhages at histology examination.
Conclusions
Based on the result of this study, it is concluded that the test item
has no acute toxic potential and that the LD50 value is higher than 2000
mg/kg after single oral administration in rats.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the study conducted this substance has no acute toxic potential by oral application. The LD50 value is higher than 2000 mg/kg bodyweight.
- Executive summary:
This study was performed according to GLP and the methods applied are fully compliant with OECD TG 423. The LD50 value of the test material is higher than 2000 mg/kg bodyweight.
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