Registration Dossier
Registration Dossier
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EC number: 203-455-5 | CAS number: 107-03-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No OECD 209 study is available for propane-1-thiol therefore reliable measured data are read across from the analogue substance propane-2-thiol. The toxicity of propane-2-thiol to micro-organisms gives a 3 hour EC50 of 880.5 mg/l (Feil, 2010).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 880.5 mg/L
- EC10 or NOEC for microorganisms:
- 1 mg/L
Additional information
Feil (2010) is a GLP-compliant study following OECD guideline 209. The study was conducted in a closed system due the volatile nature of the substance. The minor deviations in substance storage are not considered to have affected the outcome of the experiment. The study is considered reliable and suitable for use for this endpoint.
Both propane-1-thiol and propane-2-thiol have the same molecular weight and are characterised by an SH functional group with an aliphatic carbon chain. The substances vary slightly in having straight and branched aliphatic carbon chains respectively, but the similarities of the physico-chemical, environmental fate and ecotoxicity properties are apparent. Read-across of the microorganism toxicity data is therefore considered to be appropriate.
In addition, the toxicity control of a ready biodegradability study showed that propane-1-thiol is not inhibitory to micro-organisms at a concentration of 1 mg/L. Micro-organisms from a predominantly domestic sewage treatment plant were exposed to 1 mg/L propane-1-thiol for 28 days in dark glass closed biological oxygen demand bottles. The data are taken from Harlan (2012), an unpublished experimental, ready biodegradability study following OECD 301D, which is GLP-compliant. The study is considered to be reliable without restrictions.
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