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EC number: 202-815-9 | CAS number: 100-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-03-31 to 2017-04-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- effusion method: Knudsen cell
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.42 Pa
- Remarks on result:
- other: calculated
- Temp.:
- 25 °C
- Vapour pressure:
- 0.71 Pa
- Remarks on result:
- other: calculated
- Temp.:
- 50 °C
- Vapour pressure:
- 7.9 Pa
- Remarks on result:
- other: calculated
- Conclusions:
- The vapour pressure of the test item was assessed according to OECD Guideline 104 and EU Method A.4 and calculated by interpolation and extrapolation of the measured vapour pressure curve. The vapour pressure of the test item was calculated to be 0.42 Pa at 20 °C, 0.71 Pa at 25 °C and 7.9 Pa at 50 °C.
- Executive summary:
The vapour pressure of the test item was determined according to OECD Guideline 104 and EU Method A.4 in compliance with the GLP principles. Before the vapour pressure was measured, the thermal stability of the test item was assessed via Difference Scanning Calometry (DSC) in a closed glass crucible under nitrogen from room temperature up to a temperature of 300 °C with a heating rate of 3 K/min. In the range of 30 -50 °C, an endothermic effect (melting) was observed. No further thermal effects were noted up to the maximum test temperature of 300 °C. For the main test, the test item was brought into the Knudsen cell before the test and was attached to a magnetic suspension balance. After that, the system was closed and the apparatus was evacuated (approximately 10-6 Pa). A total of 7 segments were prepared for the entire measurement (temperature range: 20 to 51 °C). The series of segments commenced at the lowest desired measuring temperature. While measuring of each single segment, the decrease of weight of the Knudsen cell was measured by the magnetic suspension balance. Taking into account the geometry of the Knudsen cell orifice, physical data of the test item and the evaporation rate, the vapour pressure was calculated by interpolation and extrapolation of the measured vapour pressure curve. In result, the vapour pressure of the test item was calculated to be 0.42 Pa at 20 °C, 0.71 Pa at 25 °C and 7.9 Pa at 50 °C.
Reference
Thermal stability
In the range of 30 -50 °C of DSC run PN13147, an endothermic effect (melting) was observed. No further thermal effects were observed up to the maximum test temperature of 300 °C.
Table 1: Results of the DSC-measurement
No. | Sample weight / mg | Start / °C | Energy / J/g |
PN13147 | 7.61 | 30 (endothermic) | 110 |
Vapour pressure
Table 2: Measured vapour pressures of the test item
Test no | Temp. [°C] | Vapour pressure [Pa] |
1 | 20.3 | 0.482 |
2 | 25.3 | 0.669 |
3 | 30.4 | 1.17 |
4 | 35.5 | 2.01 |
5 | 40.6 | 3.47 |
6 | 45.6 | 4.81 |
7 | 50.7 | 9.19 |
Description of key information
The vapour pressure of the test substance was determined to be 0.42 Pa at 20 °C.
Key value for chemical safety assessment
- Vapour pressure:
- 0.42 Pa
- at the temperature of:
- 20 °C
Additional information
Discussion
The vapour pressure of the test item was determined according to OECD Guideline 104 and EU Method A.4 in compliance with the GLP principles (Symrise AG, 2017). Before the vapour pressure was measured, the thermal stability of the test item was assessed via Difference Scanning Calometry (DSC) in a closed glass crucible under nitrogen from room temperature up to a temperature of 300 °C with a heating rate of 3 K/min. In the range of 30 -50 °C, an endothermic effect (melting) was observed. No further thermal effects were noted up to the maximum test temperature of 300 °C. For the main test, the test item was brought into the Knudsen cell before the test and was attached to a magnetic suspension balance. After that, the system was closed and the apparatus was evacuated (approximately 10-6Pa). A total of 7 segments were prepared for the entire measurement (temperature range: 20 to 51 °C). The series of segments commenced at the lowest desired measuring temperature. While measuring of each single segment, the decrease of weight of the Knudsen cell was measured by the magnetic suspension balance. Taking into account the geometry of the Knudsen cell orifice, physical data of the test item and the evaporation rate, the vapour pressure was calculated by interpolation and extrapolation of the measured vapour pressure curve. In result, the vapour pressure of the test item was determined to be 0.42 Pa at 20 °C, 0.71 Pa at 25 °C and 7.9 Pa at 50 °C (calculated).
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