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Diss Factsheets
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EC number: 613-953-8 | CAS number: 66603-10-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: The investigations were carried out according to D. N. Noakes and D. M. Sanderson (A method for determining the dermal toxicity of pesticides: Brit. Journ. Ind. Med. 26, 1969)
- Deviations:
- not specified
- Principles of method if other than guideline:
- - Principle of test:Measurement of the percutaneous LD50 of a pesticide, using the laboratory rat as a test animal.
- Short description of test conditions: the product was applied once as a 50% strength formulation in distilled water at a dosage of 2,500 mg/kg for 24 hours to the clipped skin of the back and flanks (area about 50 cm²)
- Parameters analysed / observed: percutaneous LD50 value - GLP compliance:
- not specified
- Remarks:
- GLP was not compulsory at the time the study was performed however the study has been performed under consideration of good laboratory practice. The study is scientifically valid.
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclohexylhydroxydiazene 1-oxide, potassium salt
- EC Number:
- 613-953-8
- Cas Number:
- 66603-10-9
- Molecular formula:
- C6H11KN2O2
- IUPAC Name:
- Cyclohexylhydroxydiazene 1-oxide, potassium salt
- Test material form:
- solid: particulate/powder
- Details on test material:
- Test item: (N-Cyclohexyl-diazeniumdioxy)-potassium
IUPAC name: Cyclohexylhydroxydiazene 1-oxide, potassium salt
Chemical name: Cyclohexylhydroxydiazene 1-oxide, potassium salt; synonyma: (N-Cyclohexyl-diazeniumdioxy)-potassium, K-HDO, K-NCH, Xyligen K powder, Xyligen K
Molecular formula: C6 H11 K N2 O2
Molecular mass: 182.27
Constituent 1
- Specific details on test material used for the study:
- Chemical name: N-cyclohexyldiazeniumdioxy potassium
Test substance no.: XXV 210
The product was applied as a 50% strength formulation in distilled water at a dosage of 2500 mg/kg
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. WIGA, Sulzfeld, FRG
- Females (if applicable) nulliparous and non-pregnant: yes
- Age / Weight at study initiation: male animals: 157 g (mean weight); female animals: 139 g (mean weight)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: about 50 cm²
- Type of wrap if used: aluminum foil
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washing with warm water or a mixture of water and lutrol
- Time after start of exposure: The dressing was removed after the exposure time of 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2500 mg/kg
- Concentration (if solution): The product was applied as a 50% strength formulation in distilled water
- Constant volume or concentration used: yes
VEHICLE
- distilled water - Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- 5 animals per sex and dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1 h, 24 h, 48 h, 7 days, 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: Mortality within 14 days, signs of toxicity due to absorption and local irritation, Necropsy of the animals which were sacrificed with carbon dioxide at the end of the observation period - Statistics:
- Determination of median lethal dose
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The animals were lively during and after the administration and in the 14-day observation period.
- Clinical signs:
- other: No signs of toxicity observed; local irritation: none
- Gross pathology:
- Animals which were sacrificed: organs normal.
- Other findings:
- None observed
Any other information on results incl. tables
Results mortality
|
died within |
||||||
Dose |
Conc. |
Number of animals |
1 h |
24 h |
48 h |
7 days |
1 4 days |
2500 |
50 |
5 m |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 f |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
Applicant's summary and conclusion
- Conclusions:
- The percutaneous LD50 value of rats is for both sexes above 2500 mg/kg bw. The product is dermally non-toxic at least up to a concentration of 2500 mg/kg bw
- Executive summary:
MORTALITY: no mortality
CLINICAL SIGNS: no abnormalities
SKIN FINDINGS: no abnormalities
NECROPSY FINDINGS: no findings
POTENTIAL TARGET ORGANS: no findings at the internal organs
SEX-SPECIFIC DIFFERENCES: no findingsSigns of toxicity due to the absorption: The animals were lively during and after the administration and in the 14-days observation period.
Local irritation: none
Necropsy: Animals which were sacrificed: organs normal.
The median lethal dose was > 2500 mg/kg (50%w/w KHDO)/kg bw corresponds to > 1250 mg K-HDO/kg bw
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