Divinylbenzene

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from authoritative database

Data source

Reference

Reference Type:

other: authoritative database

Title:

HSDB for the CAS: 1321-74-0

Author:

US National Library of Medicine

Year:

2009

Bibliographic source:

Hazardous substance Databank, US National Library of Medicine, last updated 2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To assess the dermal irritation potential of divinyl benzene in rabbits

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Divinylbenzene

EC Number:

215-325-5

EC Name:

Divinylbenzene

Cas Number:

1321-74-0

Molecular formula:

C10H10

IUPAC Name:

1,2-di(ethenyl)benzene

Test material form:

liquid

Details on test material:

- Name of test material : 1,2-di(ethenyl)benzene- Common Name : Divinylbenzene- Molecular formula : C10H10- Molecular weight : 131.1969 g/mol- Smiles notation : C=CC1=CC=CC=C1C=C- InChl : MYRTYDVEIRVNKP-UHFFFAOYSA-N- Substance type: Organic- Physical state: Liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Divinylbenzene- Molecular formula: C10H10- Molecular weight: 131.1969 g/mol- Smiles notation: C=CC1=CC=CC=C1C=C- InChl: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Substance type: Organic- Physical state: Liquid

Test animals

Species:

rabbit

Strain:

not specified

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

1-2 ml of a mixture containing 55% divinyl benzene isomers and 40% ethyl vinyl benzene isomers

Duration of treatment / exposure:

5 days/week for 2 weeks

Observation period:

14 days

Number of animals:

No data available

Details on study design:

No data available

Results and discussion

In vitro

Other effects / acceptance of results:

No data available

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

14 d

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Irritant / corrosive response data:

Slight erythema, edema and moderate exfoliation at application site resulted was observed after 14 days. Slight to moderate necrosis followed which resulted in scar formation

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

Slight erythema, edema and moderate exfoliation at application site resulted was observed after 14 days. Slight to moderate necrosis followed which resulted in scar formation.Hence, repeated exposure of divinyl benzene can be considered to be irritating to rabbit skin.

Executive summary:

A skin irritation study was performed in rabbits to assess the irritation potential of divinyl benzene.

 

1-2 ml of a mixture containing 55% divinyl benzene isomers and 40% ethyl vinyl benzene isomers was applied to the shaved skin of rabbits under occlusive conditions5 days/week for 2 weeks. The test sites were observed for Slight erythema, edema and moderate exfoliation at application site resulted was observed after 14 days. Slight to moderate necrosis followed which resulted in scar formation.

Hence, repeated exposure of divinyl benzene can be considered to be irritating to rabbit skin.and edema till 14 days.