2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-8-[2-[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, sodium salt (1:4)

Endpoint summary

Description of key information

Bioaccumulation: aquatic/sediments:

BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2018) was used to predict the bioconcentration factor (BCF) of test chemical 2-Naphthalenesulfonic

acid, 7-amino-4-hydroxy-3-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-8-[2-[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, sodium salt (1:4)

(CAS No.607724 -87 -6). The bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-8-[2-[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, sodium salt (1:4) is not expected to bioaccumulate in the food chain.

Additional information

Bioaccumulation: aquatic/sediments:

Predicted data study for target chemical 2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-8-[2-[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, sodium salt (1:4) (CAS no. 607724-37-8) and experimental study for its structurally similar read across chemical have been reviewed for bioaccumulation endpoint and their results are summarized below.

 

The first study was predicted data study in this study the BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2018) was used to predict the bioconcentration factor (BCF) of test chemical 2 -Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-8-[2-[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, sodium salt (1:4) (CAS No. 607724 -87 -6). The bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-8-[2-[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, sodium salt (1:4) is not expected to bioaccumulate in the food chain.

 

To support the above predicted data study experimental study was reviewed from authoritative database (J check) in this study the Bioaccumulation experiment was conducted for 6 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio. 

The vehicle used in the study was HCO-40, Crystal sugar,

Concentration of vehicle: 1st Concentration area: HCO-40 14 ppm(w/v), Crystal sugar 14 ppm(w/v), 2nd Concentration area: HCO-40 1.4 ppm(w/v) Crystal sugar 1.4 ppm(w/v)

Recovery ratio : Test water : 1st concentration area : 96.1 %, 2nd concentration area : 95.4 %, Fish : 79.8 %, - Limit of detection : Fish : 0.25 ppm

 

The Nominal concentrations used in the study was 1st Concentration area: 0.7 mg/L(w/v), 2nd Concentration area: 0.07 mg/L (w/v)and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h>= 420 ppm(w/v).Thus according to static Fish test the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 0.9 – 1.8 L/kg at dose concentration 0.7 mg/L and 8.5 - 15 L/kg at dose concentration 0.07 mg/L on test organism Cyprinus carpio during 6 weeks period. Therefore it is concluded that test chemical is non bioaccumulative.

 

 

Another experimental study was also reviewed from authoritative database (J check) in this study the Bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of chemical . The study was performed according to OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) and other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively at a temperature of 25°C. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study was 0.3mg/land 0.03 mg/l, respectively. Test chemical solution was prepared in HCO-40 and Crystal sugar. Analytical method involve the recovery ratio: Fish : 79.6 %, - Limit of quantitation : Test water : 1st concentration area : 0.017 microg/mL, 2nd concentration area : 0.00 microg/mL, Fish : 0.18 microg/g. Range finding study involve theLC50(48h) >= 50.0 mg/L on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance on Cyprinus carpio was determined to be in the range of ≤ 0.7-1.8 L/Kg at a conc. of 0.3 mg/l and ≤ 6.9 L/Kg at a conc. of 0.03 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is not expected to bioaccumulate in the food chain.

 

 By considering all the studies mentioned above it can be conclude that test 2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-8-[2-[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, sodium salt (1:4) (CAS no. 607724-37-8) is non bioaccumulative in nature.