Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-178-8 | CAS number: 3025-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 25 - April 22, 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: Two animals are dosed at 5.0 g/kg dermally. If either of these animals die, then three additional groups are given various doses to determine the LD50. If neither animal in the initial dose group die, then an additional eight animals are dosed at 5.0 g/kg.
- Short description of test conditions: Dermal exposure for 24 hrs with occlusive covering.
- Parameters analysed / observed: mortality, toxicity, pharmacological effect, body weight, gross pathology - GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl (2E,4Z)-2,4-decadienoate
- EC Number:
- 221-178-8
- EC Name:
- Ethyl (2E,4Z)-2,4-decadienoate
- Cas Number:
- 3025-30-7
- Molecular formula:
- C12H20O2
- IUPAC Name:
- ethyl deca-2,4-dienoate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals
- Weight at study initiation: 2.1-2.4 kg
- Fasting period before study: no
- Housing: 2 per cage in suspended wire mesh cages
- Diet (e.g. ad libitum): Purina Rabbit Chow ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): controlled
Administration / exposure
- Type of coverage:
- occlusive
- Details on dermal exposure:
- TEST SITE
- Area of exposure: abdomen
- % coverage: 10
- Type of wrap if used: gauze covered with plastic
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 11.7-13.3 cc
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped
- Time after start of exposure: 24 hrs
- Duration of exposure:
- 24 hrs
- Doses:
- 5.0 g/kg
- No. of animals per sex per dose:
- 1 Female
9 Male - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily (observations), pretest and prior to sacrifice (weighing)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology, dermal irritation
Dermal irritation scoring:
Erythema
0 - no erythema
1 - very slight erythema (barely perceptible)
2 - well defined erythema
3 - moderate to severe erythema
4 - very severe erythema (beet redness) to slight eschar formation (injuries in depth)
Edema
0 - no edema
1 - very slight edema (barely perceptible)
2 - slight edema (edges of area well defined by definate raising)
3 - moderate edema (raised approximately 1 mm)
4 - severe edema (raised more than 1 mm and extending beyond the area of exposure)
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Yellow nasal discharge (2 animals) Few feces (2 animals) Ptosis (1 animal)
- Gross pathology:
- Lungs congested (4 animals)
Intestinal contents fluid (1 animal)
Treated skin eschar (4 animals) - Other findings:
- 40% of the test substance remained on the animals, gauze, and occlusive binding after the binding was removed. All but one animals showed severe erythema with flaking by the day 7 observation. In four of the animals, the severe erythema and flaking was still present on day 14. The remaining animal showed well defined erythema on day 7 with flaking, and still showed slight erythema with flaking on day 14. All animals showed very slight to slight edema by day 1, and four animals still showed very slight edema on day 14.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 > 5 g/kg.
- Executive summary:
The acute dermal toxicity of ethyl decedienoate was determined. Two animals were dosed at 5.0 g/kg dermally. If either of these animals die, then three additional groups are given various doses to determine the LD50. If neither animal in the initial dose group die, then an additional eight animals are dosed at 5.0 g/kg. As the two initial animals did not die, an additional 8 animals were dosed at 5.0 g/kg. Dermal exposure was for 24 hrs with occlusive covering. Animals were observed for mortality, toxicity, pharmacological effect, body weight, dermal irriation and gross pathology. No animals died during the study. The acute dermal LD50 in rabbits is > 5 g/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.