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Diss Factsheets
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EC number: 236-885-7 | CAS number: 13532-94-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- other: Expert Assessment
- Adequacy of study:
- key study
- Study period:
- 27/11/2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed to investigate the possibility to apply Annex XI adaptation rules based on exposure to the substance.
Data source
Reference
- Reference Type:
- other: Expert assessment
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was performed to investigate the possibility to apply Annex XI adaptation rules based on exposure to the substance.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-butoxyethyl methacrylate
- EC Number:
- 236-885-7
- EC Name:
- 2-butoxyethyl methacrylate
- Cas Number:
- 13532-94-0
- Molecular formula:
- C10H18O3
- IUPAC Name:
- 2-butoxyethyl 2-methylprop-2-enoate
Constituent 1
Results and discussion
Effect levels
- Key result
- Remarks on result:
- other: An assessment was performed based on available information and uses of the substance. According to section 8.6.1.of REACH, testing for short-term repeated-dose toxicity does not need to be conducted if relevant human exposure can be excluded.
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- According to section 8.6.1.of Annex VIII of the REACH regulation ((EC) No 1907/2006), testing for short-term repeated-dose toxicity does not need to be conducted if relevant human exposure can be excluded in accordance with Annex XI Section 3. It was concluded that the use of Annex XI to waive the short-term repeated dose toxicity study based on exposure to the substance was appropriate.
- Executive summary:
An assessment in accordance with REACH regulation ((EC) No 1907/2006) was performed to consider the prospect to apply Annex XI adaption rules based on exposure to 2-butoxyethylmethacrylate. According to section 8.6.1. of Annex VIII of the REACH regulation ((EC) No 1907/2006), testing for short-term repeated-dose toxicity does not need to be conducted if relevant human exposure can be excluded in accordance with Annex XI Section 3. It was concluded that the use of Annex XI to waive the short-term repeated dose toxicity study based on exposure to the substance was appropriate. Further testing is therefore considered not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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