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Diss Factsheets
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EC number: 907-237-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- non-GLP, pre-OECD
- Justification for type of information:
- The information is used for read across to Intreleven aldehyde.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result derived from read across is sufficiently reliable because all Annex XI criteria are met.
- Justification for type of information:
- The read across justification is presented in the Endpoint summary and the accompanying files are also attached there.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- other: Not acute toxic
- Remarks:
- according to EU CLP criteria (1272/2008/EC and its updates)
- Conclusions:
- Based on the results of the study for read-across substance Undec-10-enal, an acute dermal LD50 of >5000 mg/kg bw was determined for Intreleven aldehyde.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Undec-10-enal
- EC Number:
- 203-973-1
- EC Name:
- Undec-10-enal
- Cas Number:
- 112-45-8
- Molecular formula:
- C11H20O
- IUPAC Name:
- undec-10-enal
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5-3 kg
- Housing: Individually
- Diet (e.g. ad libitum): commercial diet
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 240 cm2
- % coverage: 10% of body surface
- clipped (in half of the animals the skin was lightly abraded)
- Type of wrap: the liquid test material was delivered under a rubber sleeve by using a hypodermic syringe, then the sleeve was covered with Webril padding. The rabbit was fitted with a collar to prevent the removal of the wrapping. - Duration of exposure:
- 24 hours
- Doses:
- 5 ml/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: toxic signs, (local) dermal effects and mortality.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal died during the study, no postmortem abnormalities were found.
- Clinical signs:
- Edema was found in 3/6 animals, Erythema in 5/6. Other dermal reaction occured, such as discoloration (3/6), scaling (3/6), necrosis (1/6) and eschar formation (3/6).
- Body weight:
- No information.
- Gross pathology:
- No abnormalities were found.
- Other findings:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acute toxic
- Remarks:
- according to EU CLP criteria (1272/2008/EC and its updates)
- Conclusions:
- Under the conditions of this test, an acute dermal LD50 of >5000 mg/kg bw was determined for Undec-10-enal.
- Executive summary:
An acute dermal toxicity study was performed according to a method similar to OECD TG 402, as the study was performed non-GLP and pre-OECD (it was rated Klimisch 2). In this study, 6 healthy albino rabbits were dosed dermally with Undec-10-enal at 5000 mg/kg bw. In half of the animals the skin was lightly abraded. The test article was kept in contact with the skin for 24 hours. One rabbits died and five rabbits survived the 5000 mg/kg bw dermal dose. Gross necropsy did not reveal any abnormalities. Clinical signs found were: edema (in 3/6 animals), erythema (in 5/6) and other dermal reactions occurred, such as discoloration (3/6), scaling (3/6), necrosis (1/6) and eschar formation (3/6). Under the conditions of this test, an acute dermal LD50 of >5000 mg/kg bw was determined for Undec-10-enal.
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