Orthosulfamuron

Endpoint summary

Description of key information

The 96-hour LC50 value for the Rainbow trout fish exposed to IR5878 was greater than 122 mg/L, the highest concentration tested. No mortalities or toxic effects were observed in Rainbow trout exposed to IR5878 at concentrations up to 122 mg/L. The 96-hour no mortality concentration and the NOEC were 122 mg/L.

The 96-hour NOEC and the 96-hour LC0 of IR5878 to Zebra fish were determined to be at least 100 mg/L. The 96-hour LOEC , the 96-hour LC50 and the 96-hour LC100 were clearly higher than 100 mg/L.

The 96-hour LC50 value for the Bluegill fish exposed to IR5878 was greater than 142 mg/L, the highest concentration tested. No mortalities or toxic effects were observed in Bluegill exposed to IR5878 at concentrations up to 142 mg/L. The 96-hour no mortality concentration and the NOEC were 142 mg/L.

A study was performed to evaluate the influence of IR5878 on the mobility respectively survival ofDaphnia magna. Groups of 20 youngDaphnia magnawere exposed in a static test for 48 hours to an aqueous test medium containing IR5878 at concentrations of 0,12.5, 25, 50 and 100 mg/L. The 24-hour EC₀of IR5878 was 50 mg/L. The 24-hour EC₅₀of IR5878 were clearly higher than 100 mg/L. The 24-hour EC₁₀₀of IR5878 were clearly higher than 100 mg/L. The 48-hour EC₀of IR5878 was 50 mg/L. The 48-hour EC₅₀of IR5878 were clearly higher than 100 mg/L. The 48-hour EC₁₀₀of IR5878 were clearly higher than 100 mg/L. The NOEC of IR5878 was 50 mg/L.

A study was performed to evaluate the influence of IR5878 on survival of 3-4 days old larvae ofChironomus riparius. In a limit test 4 groups of 5 first instar larvae ofChironomus ripariuswere exposed to IR5878 at the nominal concentration of 100 mg/L for 48 hours. 4 additional groups of 5 animals where used as control. The 48-hour NOEC and EC₀of IR5878 to the larvae ofChironomus ripariuswere determined to be at least 100 mg/L (the only tested concentration). The 48-hour LOEC and the 48-hour EC₅₀were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity of IR5878 up to the highest test concentration.

A study was performed to determine the toxicity of IR5878 to the red swamp crayfish (Procambarus clarkii) during a 96-hour exposure period under static test conditions. Crayfish were exposed to a geometric series of five test concentrations (7.5, 15, 30, 60 and 120 mg IR5878/L) and a negative (dilution water) control. The 96-hour LC₅₀value for the Crayfish (Procambarus clarkii) exposed to IR5878 was greater than 129 mg/L, the highest concentration tested. No mortalities or effects were observed in Crayfish exposed to IR5878 at concentrations up to 129 mg/L. The 96-hour no mortality concentration and the NOEC were 129 mg/L. Measured tissue concentrations of IR5878 in the Crayfish ranged from below the LOQ up to 1.99 µg a.s./g.

A study was performed to determine the median lethal concentration (LC₅₀) of IR5878 to pond snail (Lymnaea stagnalis). Based on the results of a range finding test, the definitive test was carried out at nominal concentrations of IR5878 of12.5, 25, 50 and 100 mg/L. The test was carried out under static conditions over a 96 hours period. The 96-hour LC₅₀of IR5878 to pond snail was estimated to be > 100 mg/L and the 96-hour NOEC to be 100 mg/L, under the conditions of the test.

A study was performed to evaluate the inhibitory effect of IR5878 on the growth of the freshwater green algal speciesScenedesmus subspicatus. Groups of 3 parallel exponentially growing cultures were treated at the concentrations of 4.6, 10, 21, 46 and 100 mg/L and incubated in a water bath.EC₅₀(biomass) was 41.4 mg/L. EC₅₀(growth rate) was 87.1 mg/L. NOEC (72-h) for biomass and growth rate was 10 mg/L. LOEC (72-h) for biomass and growth rate was 21 mg/L.

A study was performed to evaluate the inhibitory effect of IR5878 on the growth of the freshwater blue algal speciesAnabaena flos-aquae. Groups of 3 parallel exponentially growing cultures were treated at the concentrations of 0.46, 1.0, 2.1, 4.6, 10 and 21 mg/L and incubated in a water bath. EC₅₀(biomass) was 1.9 mg/L. EC₅₀(growth rate) was 13.0 mg/L. NOEC (72-h) for biomass was mg/L. NOEC (72-h) for growth rate wasmg/L. LOEC (72-h) for biomass wasmg/L. LOEC (72-h) for growth rate was 0.79 mg/L.