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EC number: 200-389-9 | CAS number: 58-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Peer reviewed study performed following the method of Draize, method well documented, without detailed results documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Draize Test: the substance to be tested is applied in a single dose to one of the eyes of the experimental animal; the untreated eye serves as the control. The degree of eye irritation/corrosion is evaluated by scoring lesions of conjunctiva, cornea, and iris, at specific intervals.
- GLP compliance:
- no
Test material
- Reference substance name:
- Adenosine
- EC Number:
- 200-389-9
- EC Name:
- Adenosine
- Cas Number:
- 58-61-7
- Molecular formula:
- C10H13N5O4
- IUPAC Name:
- adenosine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Japanese white
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Takeo Breeder (Shizuoka, Japan)
- Age at study initiation: not specified
- Sex: female
- Weight at study initiation: 2.0 -2.2 kg
- Housing: Metal cages (39 x 40 x 44 cm)
- Diet: RC4 Diet (Oriental Yeast Co., Tokyo, Japan) ad libitum
- Water: ad libitum
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25 +/- 1 °C
- Humidity (%): 55 +/- 5 %
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12 h dark/light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: right eye was left untreated as blank
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- Chemicals were not rinsed
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- Three
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
SCORING SYSTEM:
Cornela opacity, erythema, chemosis, secretat and iritis were classified using the Draize score.
Observation: 1, 4, 24, 72, 96 hr, 7, 14 and 21 days after treatment with the chemical
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Substance was classified in a group of chemicals that produce no or minimal irritation fully reversible within 24 h
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Substance was classified in a group of chemicals that produce no or minimal irritation fully reversible within 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Substance was classified in a group of chemicals that produce no or minimal irritation fully reversible within 24 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Substance was classified in a group of chemicals that produce no or minimal irritation fully reversible within 24 h
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Adenosine (CAS 58-61-7) was classified into a group of chemicals that induce no or minimal irritation, which is fully reversible after 24 h. Therefore, Adenosine does not require classification according to the UN GHS classification and the CLP classification system.
- Executive summary:
This study was performed to correlate eye irritation ratings with molecular descriptors and develope a QSAR model.
130 heterogeneous chemicals were tested, among them Adenosine (CAS 58-61-7).
100 mg or 0.1 ml of the test chemicals were placed in the conjuctival sac of the left eye of 3 female japanese white rabbits. The left eye was left untreated as blank. The grade of ocular reaction was recorded at defined intervals up to 21 days. The chemicals were classified in three categories: Class I chemicals induced no or minimal irritation that fully reversed in 24 h, Class II chemicals induced damages persisting for more that 24 h, but fully recovering until 21 days, and Class III chemical which induced damages that were not reversible after 21 days.
Adenosine (CAS 58-61-7) was classified as Class I: chemicals that induce no or minimal irritation fully reversible after 24 h.
Therefore, Adenosine does not require classification according to the UN GHS classification and the CLP classification system.
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