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EC number: 232-266-0 | CAS number: 7803-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
The acute oral median lethal dose (LD50) for the test chemical using rats was determined to be 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Ammonium phosphinate (CAS no.: 7803-65-8) cannot be classified for acute oral toxicity and is classified as "Not classified"
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data from various test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the experimental data from various test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- WoE for the target CAS is summarized based on data from various test chemicals
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 2. TEST ANIMALS
- Source: No data
- Females (if applicable) nulliparous and non-pregnant: [yes/no]
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: Yes, further details are not available
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: To: No data
3. No data
4. No data - Route of administration:
- other: Oral : 2. gavage; 3. unspecified, 4. unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- 2. VEHICLE
- Concentration in vehicle: 0, 2000 or 5000 mg/Kg
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: Test chemical solubility
- Lot/batch no. (if required): No data
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
DOSAGE PREPARATION (if unusual): The test chemical was prepared in water at dose level of 0, 2000 or 5000 mg/Kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data
3. No data
4. No data - Doses:
- 2. 0, 2000 or 5000 mg/kg bw
3. 7640 mg/kg
4. 5750 mg/Kg - No. of animals per sex per dose:
- 2. 20 males and 10 females
- 2000 mg/kg: 10 males
- 5000 mg/kg: 10 males and 10 females
3. No data
4. No data - Control animals:
- yes
- Remarks:
- 2. Yes, 3/4. No data
- Details on study design:
- 2. - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 14 days following the single administration of the test item
- Necropsy of survivors performed: yes
- Other -examinations performed: Clinical signs, mortality and body weight. Animals were subjected to necropsy and gross pathology was also performed
3. - Other examinations performed: mortality
4. - Other examinations performed: mortality - Statistics:
- No data available
- Preliminary study:
- 2. Based on a previous study (not available) indicating that LD50 was greater than 1000 mg/kg in male rats, the first dose of the test chemical to be tested in male rats was 2000 mg/kg. The other tested dose-level administered was 5000 mg/kg (1 group of females, 1 group of males).
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- 2. - At 2000 mg/kg , no mortality occurred.
- At 5000 mg/kg, 3 out of 10 males and 6 out 10 females died on day 2.
- In the negative control groups, no deaths occurred.
3. 50% mortality was observed at 7650 mg/Kg
4. 50% mortality was observed at 5750 mg/Kg - Clinical signs:
- 2. - In males exposed to 2000 mg/kg, mild depression and piloerection were observed from day 1 (1 hour after dosing) to day 2.
- In males and females exposed to 5000 mg/kg, mild depression and piloerection were observed from day 1 (immediately after dosing) to day 3.
- There were no clinical signs in the negative control groups.
3. No data
4. No data - Body weight:
- 2. At dose levels 2000 and 5000 mg/kg, body weight gain was similar to controls and no apparent abnormalities were observed at necropsy.
3. No data
4. No data - Gross pathology:
- 2. Red lungs and stomachs filled with a clear watery fluid were reported in the 3 males and 6 females found dead in the 5000 mg/kg bw groups.
3. No data
4. No data - Other findings:
- No data
- Interpretation of results:
- other: Not Classified
- Conclusions:
- The acute oral median lethal dose (LD50) for the test chemical using rats was determined to be 2000 mg/kg bw.
- Executive summary:
Data available from the various test chemicals was reviewed to determine the toxic nature of the test chemical. The studies are as mentioned below:
Acute oral toxicity of test chemical was examined in rats according to methods similar to OPPTS 870.1100 and OECD 401 guidelines. The 14 days study was performed using rats. The test chemical was prepared in water and was administered by gavage under a dosage-volume of 10 mL/kg bw to groups of 10 fasted rats. Based on a previous study details indicating that LD50 was greater than 1000 mg/kg in male rats, the first dose of the test item to be tested in male rats was 2000 mg/kg. The other tested dose-level administered was 5000 mg/kg (1 group of females, 1 group of males). Negative control groups receiving water only were included in the study. Clinical signs, mortality and body weight were checked for a period of 14 days following the single administration of the test item. All animals were subjected to necropsy and gross pathology was also performed. At the dose-level of 2000 mg/kg, no mortality occurred. Mild depression and piloerection were observed from day 1 (1 hour after dosing) to day 2. Body weight gain was similar to controls and no apparent abnormalities were observed at necropsy. At the dose- level of 5000 mg/kg, 3 out 10 males and 6 out 10 females were found dead on day 2. At necropsy, red lungs and stomachs filled with a clear watery fluid were reported in those animals. In the surviving animals, mild depression and piloerection were observed from day 1 (immediately after dosing) to day 3. Body weight gain was similar to controls and no apparent abnormalities were observed at necropsy. Under the experimental conditions of this study, the acute oral median lethal dose (LD50) for the test chemical in male rats was determined to be >5000 mg/kg and in female rats, the LD50 was considered to be 2000-5000 mg/kg bw.
Acute oral toxicity study of the test chemical was conducted in rat at the concentration of 7640 mg/kg bw. 50% mortality was observed at 7640 mg/kg bw. Therefore, the acute oral median lethal dose (LD50) was considered to be 7640 mg/kg bw, when rats were treated with test chemical orally.
Acute oral toxicity study of the test chemical was conducted in rats at the concentration of 5750 mg/kg bw. 50% mortality was observed at 5750 mg/kg bw. Therefore, LD50 was considered to be 5750 mg/ kg bw, when rats were treated with test chemical orally.
Based on the data available and applying weight of evidence approach, the acute oral median lethal dose (LD50) for the test chemical using rats was determined to be 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from database.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
Data available from the various test chemicals was reviewed to determine the toxic nature of the test chemical. The studies are as mentioned below:
Acute oral toxicity of test chemical was examined in rats according to methods similar to OPPTS 870.1100 and OECD 401 guidelines. The 14 days study was performed using rats. The test chemical was prepared in water and was administered by gavage under a dosage-volume of 10 mL/kg bw to groups of 10 fasted rats. Based on a previous study details indicating that LD50 was greater than 1000 mg/kg in male rats, the first dose of the test item to be tested in male rats was 2000 mg/kg. The other tested dose-level administered was 5000 mg/kg (1 group of females, 1 group of males). Negative control groups receiving water only were included in the study. Clinical signs, mortality and body weight were checked for a period of 14 days following the single administration of the test item. All animals were subjected to necropsy and gross pathology was also performed. At the dose-level of 2000 mg/kg, no mortality occurred. Mild depression and piloerection were observed from day 1 (1 hour after dosing) to day 2. Body weight gain was similar to controls and no apparent abnormalities were observed at necropsy. At the dose- level of 5000 mg/kg, 3 out 10 males and 6 out 10 females were found dead on day 2. At necropsy, red lungs and stomachs filled with a clear watery fluid were reported in those animals. In the surviving animals, mild depression and piloerection were observed from day 1 (immediately after dosing) to day 3. Body weight gain was similar to controls and no apparent abnormalities were observed at necropsy. Under the experimental conditions of this study, the acute oral median lethal dose (LD50) for the test chemical in male rats was determined to be >5000 mg/kg and in female rats, the LD50 was considered to be 2000-5000 mg/kg bw.
Acute oral toxicity study of the test chemical was conducted in rat at the concentration of 7640 mg/kg bw. 50% mortality was observed at 7640 mg/kg bw. Therefore, the acute oral median lethal dose (LD50) was considered to be 7640 mg/kg bw, when rats were treated with test chemical orally.
Acute oral toxicity study of the test chemical was conducted in rats at the concentration of 5750 mg/kg bw. 50% mortality was observed at 5750 mg/kg bw. Therefore, LD50 was considered to be 5750 mg/ kg bw, when rats were treated with test chemical orally.
Based on the data available and applying weight of evidence approach, the acute oral median lethal dose (LD50) for the test chemical using rats was determined to be 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Ammonium phosphinate (CAS no.: 7803-65-8) cannot be classified for acute oral toxicity and is classified as "Not classified"
Justification for classification or non-classification
Based on the data available and applying weight of evidence approach, the acute oral median lethal dose (LD50) for the test chemical using rats was determined to be 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Ammonium phosphinate (CAS no.: 7803-65-8) cannot be classified for acute oral toxicity and is classified as "Not classified"
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